{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,10]],"date-time":"2025-12-10T12:36:24Z","timestamp":1765370184433,"version":"3.41.2"},"reference-count":17,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["SAGE Open Medical Case Reports"],"published-print":{"date-parts":[[2023,1]]},"abstract":"<jats:p> Tolvaptan is the current standard of treatment for autosomal dominant polycystic kidney disease. It operates by acting on V2 receptors and blocks vasopressin interactions, causing a reduction in the rate of renal cyst growth and preserving kidney function. The current known risks of tolvaptan involve a serious liver injury characterized by an elevation in total bilirubin and alanine transaminase and aspartate transaminase levels. In this report, we document a unique liver injury characterized by an elevated bilirubin with normal alanine transaminase and aspartate transaminase levels in a patient who is homozygous for the UGT1A1 consistent with Gilbert syndrome. <\/jats:p>","DOI":"10.1177\/2050313x231169841","type":"journal-article","created":{"date-parts":[[2023,4,29]],"date-time":"2023-04-29T10:37:52Z","timestamp":1682764672000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":2,"title":["Tolvaptan-induced isolated elevation of bilirubin in a patient with Gilbert syndrome"],"prefix":"10.1177","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6517-041X","authenticated-orcid":false,"given":"Matthew","family":"Nguyen","sequence":"first","affiliation":[{"name":"Division of Nephrology, Hypertension & Kidney Transplantation, Department of Medicine, University of California, Irvine Medical Center, Irvine, CA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Beshoy T","family":"Yanny","sequence":"additional","affiliation":[{"name":"Vatche & Tamar Manoukian Division of Digestive Diseases, Department of Medicine, University of California, Los Angeles, Los Angeles, CA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tai LD","family":"Truong","sequence":"additional","affiliation":[{"name":"Division of Nephrology, Hypertension & Kidney Transplantation, Department of Medicine, University of California, Irvine Medical Center, Irvine, CA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hongyu","family":"Zhao","sequence":"additional","affiliation":[{"name":"Division of Nephrology, Hypertension & Kidney Transplantation, Department of Medicine, University of California, Irvine Medical Center, Irvine, CA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ramy","family":"Hanna","sequence":"additional","affiliation":[{"name":"Division of Nephrology, Hypertension & Kidney Transplantation, Department of Medicine, University of California, Irvine Medical Center, Irvine, CA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2023,4,29]]},"reference":[{"key":"bibr1-2050313X231169841","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMcp0804458"},{"key":"bibr2-2050313X231169841","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(07)60601-1"},{"key":"bibr3-2050313X231169841","doi-asserted-by":"publisher","DOI":"10.1038\/nrneph.2011.109"},{"key":"bibr4-2050313X231169841","doi-asserted-by":"publisher","DOI":"10.1152\/ajprenal.00243.2011"},{"key":"bibr5-2050313X231169841","doi-asserted-by":"publisher","DOI":"10.1124\/jpet.114.213256"},{"key":"bibr6-2050313X231169841","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1205511"},{"key":"bibr7-2050313X231169841","doi-asserted-by":"publisher","DOI":"10.1007\/s40264-015-0327-3"},{"key":"bibr8-2050313X231169841","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1710030"},{"key":"bibr9-2050313X231169841","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gfy297"},{"key":"bibr10-2050313X231169841","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2018060590"},{"key":"bibr11-2050313X231169841","unstructured":"Tolvaptan FDA drug-label. Date unknown. Accessed March 1, 2023. https:\/\/www.accessdata.fda.gov\/drugsatfda_docs\/label\/2018\/204441lbl.pdf"},{"key":"bibr12-2050313X231169841","doi-asserted-by":"publisher","DOI":"10.1053\/j.ajkd.2022.08.012"},{"key":"bibr13-2050313X231169841","doi-asserted-by":"publisher","DOI":"10.2147\/DHPS.S142825"},{"key":"bibr14-2050313X231169841","unstructured":"Chandrasekar VT, Faust TW, John S. Gilbert syndrome. StatPearls Publishing, 2022, https:\/\/www.ncbi.nlm.nih.gov\/books\/NBK470200\/ (accessed 25 October 2022)."},{"key":"bibr15-2050313X231169841","unstructured":"PubMed. Inherited disorders of bilirubin metabolism, https:\/\/pubmed.ncbi.nlm.nih.gov\/12480568\/ (2003, accessed 25 October 2022)."},{"key":"bibr16-2050313X231169841","doi-asserted-by":"publisher","DOI":"10.1124\/dmd.118.083907"},{"key":"bibr17-2050313X231169841","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0190430"}],"container-title":["SAGE Open Medical Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/2050313X231169841","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/2050313X231169841","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/2050313X231169841","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,3,4]],"date-time":"2025-03-04T07:19:37Z","timestamp":1741072777000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/2050313X231169841"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,1]]},"references-count":17,"alternative-id":["10.1177\/2050313X231169841"],"URL":"https:\/\/doi.org\/10.1177\/2050313x231169841","relation":{},"ISSN":["2050-313X","2050-313X"],"issn-type":[{"type":"print","value":"2050-313X"},{"type":"electronic","value":"2050-313X"}],"subject":[],"published":{"date-parts":[[2023,1]]},"article-number":"2050313X231169841"}}