{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,4]],"date-time":"2026-04-04T00:47:15Z","timestamp":1775263635100,"version":"3.50.1"},"reference-count":5,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["SAGE Open Medical Case Reports"],"published-print":{"date-parts":[[2023,1]]},"abstract":"<jats:p> Nivolumab (PD-1 inhibitor) and ipilumumab (CTLA-4 inhibitor) are recently approved checkpoint inhibitors for treatment of non-small cell lung cancer. Immune-related adverse events related to the usage of checkpoint inhibitors are growing with their popularity. We present the case of a patient in combination treatment of nivolumab and ipilimumab who developed a lichenoid drug reaction, notable because it worsened to a bullous lichenoid drug reaction. Treatment with prednisone and withdrawal of checkpoint inhibitors aided in clinical resolution. Initial presentation of a lichenoid reaction that progressed to a bullous, desquamated presentation indicates the possibility of the prodromal rash progressing to a Stevens-Johnson Syndrome-like dermatosis. When dermatologists are consulted for rashes developed during checkpoint-inhibitor therapy, they should be aware that early treatment may prevent progression to bullae formation and desquamation and develop their treatment plans with this in mind. <\/jats:p>","DOI":"10.1177\/2050313x231213927","type":"journal-article","created":{"date-parts":[[2023,12,21]],"date-time":"2023-12-21T07:02:28Z","timestamp":1703142148000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":3,"title":["Lichenoid drug reaction after ipilimumab\/nivolumab combination therapy: A case report"],"prefix":"10.1177","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2133-7545","authenticated-orcid":false,"given":"Zon\u00eda Robenne","family":"Moore","sequence":"first","affiliation":[{"name":"University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA"},{"name":"Dermatology Department, Manuel Gea Gonz\u00e1lez General Hospital, Tlalpan, CDMX, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dalit","family":"Zajdman-Faitelson","sequence":"additional","affiliation":[{"name":"Dermatology Department, Manuel Gea Gonz\u00e1lez General Hospital, Tlalpan, CDMX, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Arely Tamariz","family":"Campillo","sequence":"additional","affiliation":[{"name":"Dermatology Department, Manuel Gea Gonz\u00e1lez General Hospital, Tlalpan, CDMX, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Diana Karen","family":"Brito Bustillos","sequence":"additional","affiliation":[{"name":"Dermatopathology Department, Manuel Gea Gonz\u00e1lez General Hospital, Tlalpan, CDMX, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sonia","family":"Toussaint-Caire","sequence":"additional","affiliation":[{"name":"Dermatopathology Department, Manuel Gea Gonz\u00e1lez General Hospital, Tlalpan, CDMX, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cristina","family":"Berumen-Glinz","sequence":"additional","affiliation":[{"name":"Dermatology Department, Manuel Gea Gonz\u00e1lez General Hospital, Tlalpan, CDMX, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2023,12,20]]},"reference":[{"key":"bibr1-2050313X231213927","doi-asserted-by":"publisher","DOI":"10.1136\/bcr-2022-251233"},{"key":"bibr2-2050313X231213927","doi-asserted-by":"publisher","DOI":"10.21037\/jtd.2017.12.52"},{"key":"bibr3-2050313X231213927","doi-asserted-by":"publisher","DOI":"10.1016\/S0001-7310(06)73471-8"},{"key":"bibr4-2050313X231213927","doi-asserted-by":"publisher","DOI":"10.1097\/CMR.0000000000000500"},{"key":"bibr5-2050313X231213927","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijom.2018.07.025"}],"container-title":["SAGE Open Medical Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/2050313X231213927","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/2050313X231213927","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/2050313X231213927","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,3,2]],"date-time":"2025-03-02T19:49:13Z","timestamp":1740944953000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/2050313X231213927"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,1]]},"references-count":5,"alternative-id":["10.1177\/2050313X231213927"],"URL":"https:\/\/doi.org\/10.1177\/2050313x231213927","relation":{},"ISSN":["2050-313X","2050-313X"],"issn-type":[{"value":"2050-313X","type":"print"},{"value":"2050-313X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,1]]},"article-number":"2050313X231213927"}}