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This report presents the case of a 38-year-old bisexual male who consulted the infectious diseases department with non-itchy maculopapular and purpuric lesions on the skin with the involvement of the oral mucosa, suggesting a diagnosis of Kaposi\u2019s sarcoma. Biological and radiological investigations were performed. The patient was found to be human immunodeficiency virus positive with a viral load of 251.000\/mL and a CD4 count of 182\/mm<jats:sup>3<\/jats:sup>. In addition, secondary syphilis was diagnosed. Histopathological examinations confirmed HHV-8 KS. The patient was treated with Extencilline<jats:sup>\u00ae<\/jats:sup> and antiretroviral therapy. After 10 months of chemotherapy, a favorable outcome was noted with complete resolution of skin and oral mucosa lesions. <\/jats:p>","DOI":"10.1177\/2050313x241235815","type":"journal-article","created":{"date-parts":[[2024,3,4]],"date-time":"2024-03-04T08:49:14Z","timestamp":1709542154000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":2,"title":["Diffuse Kaposi sarcoma with oral involvement in a person diagnosed with human immunodeficiency virus\/acquired immune deficiency syndrome: A case report"],"prefix":"10.1177","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4076-3638","authenticated-orcid":false,"given":"Latifa","family":"Berrezouga","sequence":"first","affiliation":[{"name":"Department of Microbiology and Immunology, Faculty of Dental Medicine, University of Monastir, Monastir, Tunisia"},{"name":"Department of Endodontics, Dental Clinic, University of Monastir, Tunisia"},{"name":"Laboratory of Medical and Molecular Parasitology and Mycology LR12ES09, Faculty of Pharmacy, University of Monastir, Tunisia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4177-2221","authenticated-orcid":false,"given":"Nada","family":"Alouani","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Immunology, Faculty of Dental Medicine, University of Monastir, Monastir, Tunisia"},{"name":"Department of Endodontics, Dental Clinic, University of Monastir, Tunisia"},{"name":"Laboratory of Medical and Molecular Parasitology and Mycology LR12ES09, Faculty of Pharmacy, University of Monastir, Tunisia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1771-7038","authenticated-orcid":false,"given":"Ikbel","family":"Kooli","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases, F. 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