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In this study, we report on five clinical cases, encompassing patients aged 40\u201360 years of both sexes, who tested positive for coronavirus disease 2019 via real-time polymerase chain reaction and exhibited significant pulmonary compromise with elevated inflammatory biomarkers. These patients were treated with aerosol therapy using surfactant delivered through vibrating-mesh nebulizers alongside HFNC. Of these patients, four demonstrated positive responses to the treatment, suggesting that aerosol therapy with surfactant through vibrating-mesh nebulizers could be a viable rescue therapy in adults receiving HFNC oxygen therapy for hypoxemic respiratory failure caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Unfortunately, one patient had a negative outcome and succumbed. The findings from these cases indicate that the use of aerosol therapy with vibrating-mesh nebulizers as rescue therapy might offer an alternative approach for managing adults with hypoxemic respiratory failure due to SARS-CoV-2, as evidenced by the positive outcomes in four out of the five cases presented. <\/jats:p>","DOI":"10.1177\/2050313x241236313","type":"journal-article","created":{"date-parts":[[2024,3,4]],"date-time":"2024-03-04T08:52:41Z","timestamp":1709542361000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":1,"title":["Surfactant therapy using vibrating-mesh nebulizers in adults with COVID-19-induced ARDS: A case series"],"prefix":"10.1177","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7778-0362","authenticated-orcid":false,"given":"Killen H","family":"Briones-Claudett","sequence":"first","affiliation":[{"name":"Facultad de Medicina, Universidad de Las Americas, Quito, 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