{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,13]],"date-time":"2026-06-13T00:09:20Z","timestamp":1781309360618,"version":"3.54.1"},"reference-count":16,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["SAGE Open Medical Case Reports"],"published-print":{"date-parts":[[2024,1]]},"abstract":"<jats:p> Ectopic pregnancy is a pregnancy in which the developing blastocyst implants outside the endometrial cavity. An estimated 1.3%\u20132.4% of pregnancies end up outside the uterus. With prompt diagnosis and efficient treatment, the risks of morbidity and mortality associated with ectopic pregnancy can be reduced. For the treatment of carefully chosen ectopic pregnancies, methotrexate therapy, a folic acid antagonist that is highly toxic to rapidly replicating tissues, produces outcomes comparable to surgery. We describe six cases of ectopic pregnancy which were successfully treated with methotrexate and on follow-up two of them successfully conceived to term delivery. For patients who are physically fit enough, medical management of an ectopic pregnancy with methotrexate should be the first line of treatment to lower surgical morbidity and mortality. Following the administration of the medication, the patient is monitored with a clinical symptom interview and weekly plasma human chorionic gonadotrophin levels checks. When initial human chorionic gonadotrophin levels are extremely high, complete resolution of an ectopic pregnancy can take 6\u20138 weeks instead of the usual 2\u20133 weeks. Early diagnosis of ectopic pregnancies is necessary to improve their prognosis. Ectopic pregnancies can be managed medically with methotrexate to preserve fertility. Compared to surgical management, methotrexate therapy appears to have more advantages. <\/jats:p>","DOI":"10.1177\/2050313x241252348","type":"journal-article","created":{"date-parts":[[2024,5,20]],"date-time":"2024-05-20T11:26:03Z","timestamp":1716204363000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":1,"title":["Medical management of ectopic pregnancy: Case series at a private tertiary hospital, Tanzania"],"prefix":"10.1177","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0009-0003-6326-8434","authenticated-orcid":false,"given":"Gregory","family":"Ntiyakunze","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology, The Aga Khan University, Dar Es Salaam, Tanzania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1230-4074","authenticated-orcid":false,"given":"Daudi","family":"Gidion","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, The Aga Khan University, Dar Es Salaam, Tanzania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8251-8660","authenticated-orcid":false,"given":"Willbroad","family":"Kyejo","sequence":"additional","affiliation":[{"name":"Department of Family Medicine, The Aga Khan University, Dar Es Salaam, Tanzania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8580-7852","authenticated-orcid":false,"given":"Brenda","family":"Moshi","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, The Aga Khan University, Dar Es Salaam, Tanzania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shweta","family":"Jaiswal","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, The Aga Khan University, Dar Es Salaam, Tanzania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lynn","family":"Moshi","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, The Aga Khan University, Dar Es Salaam, Tanzania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-3714-8447","authenticated-orcid":false,"given":"Jane","family":"Muzo","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, The Aga Khan University, Dar Es Salaam, Tanzania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Harrison","family":"Chuwa","sequence":"additional","affiliation":[{"name":"Department of Oncology, The Aga Khan Hospital, Dar Es Salaam, Tanzania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Muzdalifat","family":"Abeid","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, The Aga Khan University, Dar Es Salaam, Tanzania"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2024,5,20]]},"reference":[{"key":"bibr1-2050313X241252348","unstructured":"Cunningham FG, Leveno KJ, Bloom SL, et al. 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