{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T01:57:20Z","timestamp":1789437440958,"version":"build-2803163510"},"reference-count":24,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["SAGE Open Medical Case Reports"],"published-print":{"date-parts":[[2024,1]]},"abstract":"<jats:p> Nitrous oxide, also called nitrous monoxide, or nitrous oxide, is a colorless and odorless gas, without toxicological effect, but it can be asphyxiating at high concentration, its misuse is increasing especially among young people. Chronic use of N<jats:sub>2<\/jats:sub>O may cause psychiatric complications, including depression, hypomania, and paranoid psychosis with visual and auditory hallucinations. We present a case of nitrous oxide abuse \u201claughing gas\u201d in 25 years old woman with bizarre behavior delusions and hallucinations with a normal neurological examination. The patient had low levels of vitamin B12 (135 pmol\/L). Treatment with antipsychotics and vitamin B12 (cobalamin) resolved her psychosis. In addition to the hematological and neurological effects, rare cases of acute psychosis, especially in young people with or without psychiatric history, use varies from 1 month to years. Clinicians are increasingly in need of knowledge regarding the misuse of nitrous oxide. <\/jats:p>","DOI":"10.1177\/2050313x241269577","type":"journal-article","created":{"date-parts":[[2024,8,8]],"date-time":"2024-08-08T11:27:13Z","timestamp":1723116433000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":3,"title":["Acute psychotic and vitamin B12 deficiency in patient with nitrous oxide misuse: A case report"],"prefix":"10.1177","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3686-8138","authenticated-orcid":false,"given":"Hasnaoui","family":"Mohammed","sequence":"first","affiliation":[{"name":"Department of Psychiatry, University Hospital of Mohammed VI-Oujda, Faculty of Medicine and Pharmacy of Oujda, Mohammed First University, Oujda, Morocco"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4592-8403","authenticated-orcid":false,"given":"Echater","family":"Sara","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, University Hospital of Mohammed VI-Oujda, Faculty of Medicine and Pharmacy of Oujda, Mohammed First University, Oujda, Morocco"},{"name":"Psychiatry Department, Faculty of Medicine and Pharmacy of Tangier, Universit\u00e9 Abdelmalek Essaadi, CHU Mohammed VI, Tangier, Morocco"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oneib","family":"Bouchra","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, University Hospital of Mohammed VI-Oujda, Faculty of Medicine and Pharmacy of Oujda, Mohammed First University, Oujda, Morocco"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2024,8,8]]},"reference":[{"key":"bibr1-2050313X241269577","doi-asserted-by":"publisher","DOI":"10.1053\/bean.2001.0165"},{"key":"bibr2-2050313X241269577","doi-asserted-by":"publisher","DOI":"10.1051\/ata\/2000013"},{"key":"bibr3-2050313X241269577","doi-asserted-by":"publisher","DOI":"10.1016\/j.revmed.2021.10.008"},{"key":"bibr4-2050313X241269577","doi-asserted-by":"publisher","DOI":"10.1097\/JCP.0000000000001151"},{"key":"bibr5-2050313X241269577","doi-asserted-by":"publisher","DOI":"10.3988\/jcn.2019.15.1.116"},{"key":"bibr6-2050313X241269577","doi-asserted-by":"publisher","DOI":"10.1111\/ajad.12372"},{"key":"bibr7-2050313X241269577","doi-asserted-by":"publisher","DOI":"10.1177\/0269881116632375"},{"key":"bibr8-2050313X241269577","first-page":"478","author":"van Laar M","year":"2020","journal-title":"Nationale Drug monitor"},{"key":"bibr9-2050313X241269577","doi-asserted-by":"publisher","DOI":"10.1016\/j.puhe.2021.02.036"},{"key":"bibr10-2050313X241269577","doi-asserted-by":"publisher","DOI":"10.1007\/s12640-021-00352-y"},{"key":"bibr11-2050313X241269577","doi-asserted-by":"publisher","DOI":"10.1016\/j.schres.2019.02.006"},{"key":"bibr12-2050313X241269577","doi-asserted-by":"publisher","DOI":"10.7861\/clinmedicine.19-2-129"},{"key":"bibr13-2050313X241269577","doi-asserted-by":"publisher","DOI":"10.1007\/s00213-022-06121-9"},{"key":"bibr14-2050313X241269577","first-page":"650","volume":"53","author":"Koitabashi T","year":"2004","journal-title":"Masui"},{"key":"bibr15-2050313X241269577","doi-asserted-by":"publisher","DOI":"10.1016\/j.yrtph.2015.10.017"},{"key":"bibr16-2050313X241269577","doi-asserted-by":"publisher","DOI":"10.1136\/emj.2007.057471"},{"key":"bibr17-2050313X241269577","doi-asserted-by":"publisher","DOI":"10.1017\/cjn.2014.30"},{"key":"bibr18-2050313X241269577","doi-asserted-by":"publisher","DOI":"10.1080\/15563650.2021.1938107"},{"key":"bibr19-2050313X241269577","doi-asserted-by":"publisher","DOI":"10.1016\/j.rehab.2014.12.005"},{"key":"bibr20-2050313X241269577","doi-asserted-by":"publisher","DOI":"10.1016\/j.clineuro.2013.04.004"},{"key":"bibr21-2050313X241269577","doi-asserted-by":"publisher","DOI":"10.1016\/j.psym.2013.11.001"},{"key":"bibr22-2050313X241269577","doi-asserted-by":"publisher","DOI":"10.1007\/BF03161175"},{"key":"bibr23-2050313X241269577","unstructured":"Chen T, Zhong N, Jiang H, et al. Neuropsychiatric Symptoms Induced by Large Doses of Nitrous Oxide Inhalation: A Case Report. 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