{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T02:17:10Z","timestamp":1787019430411,"version":"build-2736575974"},"reference-count":17,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["SAGE Open Medical Case Reports"],"published-print":{"date-parts":[[2025,1]]},"abstract":"<jats:p>This is a case presentation of a primary central nervous system B-cell lymphoma in a 69-year-old woman with chronic lymphocytic inflammation with pontine perivascular enhancement responsive to steroids and chronic immunosuppressive treatment. The patient had been diagnosed as having probable chronic lymphocytic inflammation with pontine perivascular enhancement responsive to steroids, according to international criteria. Afterward, regular clinical and imaging examinations and blood tests were performed. The patient presented with primary central nervous system B-cell lymphoma 3 years after the initial diagnosis of chronic lymphocytic inflammation with pontine perivascular enhancement responsive to steroids. Brain tissue histology was indicative of diffuse giant B cells, Epstein\u2013Barr virus positive, and non-Hodgkin lymphoma. The nature of chronic lymphocytic inflammation with pontine perivascular enhancement responsive to steroids is obscure, driving the formulation of many hypotheses about its causes. In our opinion, the presented case supports the putative neoplastic nature of the disease, at least in the long term, and\/or along with Epstein\u2013Barr virus involvement, which is known that have been related to other immune-mediated diseases such as multiple sclerosis and malignancies, especially with specific human leukocyte antigen haplotypes. Further research is needed and close monitoring of such patients is strongly recommended.<\/jats:p>","DOI":"10.1177\/2050313x251316764","type":"journal-article","created":{"date-parts":[[2025,1,30]],"date-time":"2025-01-30T09:48:04Z","timestamp":1738230484000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":1,"title":["Central nervous system B-cell lymphoma in a patient diagnosed with chronic lymphocytic inflammation with pontine perivascular enhancement responsive to steroids: A case report"],"prefix":"10.1177","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0009-0008-9445-7082","authenticated-orcid":false,"given":"Evangelos","family":"Koumasopoulos","sequence":"first","affiliation":[{"name":"Multiple Sclerosis and Demyelinating Diseases Unit, Center of Expertise for Rare Demyelinating and Autoimmune Diseases of CNS, First Department of Neurology, School of Medicine, National and Kapodistrian University of Athens, NKUA, Aeginition University Hospital, Athens, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Evangelia-Anna","family":"Spiteri","sequence":"additional","affiliation":[{"name":"Department of Pathology, Evaggelismos Hospital, Athens, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aigli G","family":"Vakrakou","sequence":"additional","affiliation":[{"name":"Multiple Sclerosis and Demyelinating Diseases Unit, Center of Expertise for Rare Demyelinating and Autoimmune Diseases of CNS, First Department of Neurology, School of Medicine, National and Kapodistrian University of Athens, NKUA, Aeginition University Hospital, Athens, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Panagiotis","family":"Toulas","sequence":"additional","affiliation":[{"name":"Research Unit of Radiology, Second Department of Radiology, Aeginition University Hospital, National and Kapodistrian University of Athens, Athens, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Georgios","family":"Velonakis","sequence":"additional","affiliation":[{"name":"Research Unit of Radiology, Second Department of Radiology, Aeginition University Hospital, National and Kapodistrian University of Athens, Athens, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"George","family":"Stranjalis","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, National and Kapodistrian University of Athens, Athens, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leonidas","family":"Stefanis","sequence":"additional","affiliation":[{"name":"First Department of Neurology. School of Medicine, National and Kapodistrian University of Athens, NKUA, Aeginition University Hospital, Athens, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria-Eleptheria","family":"Evangelopoulos","sequence":"additional","affiliation":[{"name":"Multiple Sclerosis and Demyelinating Diseases Unit, Center of Expertise for Rare Demyelinating and Autoimmune Diseases of CNS, First Department of Neurology, School of Medicine, National and Kapodistrian University of Athens, NKUA, Aeginition University Hospital, Athens, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8934-670X","authenticated-orcid":false,"given":"Maria","family":"Anagnostouli","sequence":"additional","affiliation":[{"name":"Multiple Sclerosis and Demyelinating Diseases Unit, Center of Expertise for Rare Demyelinating and Autoimmune Diseases of CNS, First Department of Neurology, School of Medicine, National and Kapodistrian University of Athens, NKUA, Aeginition University Hospital, Athens, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2025,1,30]]},"reference":[{"key":"bibr1-2050313X251316764","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000033211"},{"key":"bibr2-2050313X251316764","doi-asserted-by":"publisher","DOI":"10.3892\/etm.2021.10625"},{"key":"bibr3-2050313X251316764","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awq164"},{"key":"bibr4-2050313X251316764","doi-asserted-by":"publisher","DOI":"10.1097\/RHU.0000000000000238"},{"key":"bibr5-2050313X251316764","doi-asserted-by":"publisher","DOI":"10.1177\/17562864211062821"},{"key":"bibr6-2050313X251316764","doi-asserted-by":"publisher","DOI":"10.1186\/s13256-021-02814-5"},{"key":"bibr7-2050313X251316764","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp-2020-325759"},{"key":"bibr8-2050313X251316764","doi-asserted-by":"publisher","DOI":"10.1007\/s10072-020-04750-6"},{"key":"bibr9-2050313X251316764","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awx200"},{"key":"bibr10-2050313X251316764","doi-asserted-by":"publisher","DOI":"10.1007\/s10072-020-04615-y"},{"key":"bibr11-2050313X251316764","first-page":"207","volume":"48","author":"Babinski J","year":"1986","journal-title":"C R Soc Biol"},{"key":"bibr12-2050313X251316764","doi-asserted-by":"publisher","DOI":"10.1080\/09273948.2018.1449865"},{"key":"bibr13-2050313X251316764","doi-asserted-by":"publisher","DOI":"10.3390\/diagnostics10121076"},{"key":"bibr14-2050313X251316764","doi-asserted-by":"publisher","DOI":"10.1038\/s41392-023-01451-2"},{"key":"bibr15-2050313X251316764","doi-asserted-by":"publisher","DOI":"10.1007\/s10014-011-0020-x"},{"key":"bibr16-2050313X251316764","doi-asserted-by":"publisher","DOI":"10.1097\/00000478-200301000-00003"},{"key":"bibr17-2050313X251316764","doi-asserted-by":"publisher","DOI":"10.1016\/j.jns.2014.02.003"}],"container-title":["SAGE Open Medical Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/2050313X251316764","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/2050313X251316764","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/2050313X251316764","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,1,30]],"date-time":"2025-01-30T09:48:06Z","timestamp":1738230486000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/2050313X251316764"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,1]]},"references-count":17,"alternative-id":["10.1177\/2050313X251316764"],"URL":"https:\/\/doi.org\/10.1177\/2050313x251316764","relation":{},"ISSN":["2050-313X","2050-313X"],"issn-type":[{"value":"2050-313X","type":"print"},{"value":"2050-313X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,1]]},"article-number":"2050313X251316764"}}