{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,28]],"date-time":"2026-05-28T01:17:38Z","timestamp":1779931058006,"version":"3.53.1"},"reference-count":17,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["SAGE Open Medical Case Reports"],"published-print":{"date-parts":[[2025,1]]},"abstract":"<jats:p> Dupilumab, a monoclonal antibody that targets interleukin-4 and interleukin-13, is one of the approved biologic treatments for moderate-to-severe atopic dermatitis. While it is extremely well tolerated with low rates of adverse events, there have been reports of patients with atopic dermatitis managed on Dupilumab developing new-onset psoriasis. The development of psoriasis in patients with atopic dermatitis on Dupilumab therapy is believed to occur due to a decrease in T helper 2 activity and resultant dysregulation of the T helper 1 and T helper 17 pathways involved in psoriasis pathogenesis. Upadacitinib, an oral, selective Janus kinase 1 inhibitor, approved for use in moderate-to-severe atopic dermatitis as well as psoriatic arthritis may have a potential role in psoriasis treatment. We describe a case of a patient who initially presented with longstanding atopic dermatitis that underwent a psoriasiform switch while managed on Dupilumab and is currently stable on Upadacitinib. <\/jats:p>","DOI":"10.1177\/2050313x251317811","type":"journal-article","created":{"date-parts":[[2025,2,3]],"date-time":"2025-02-03T11:58:21Z","timestamp":1738583901000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":8,"title":["Dupilumab-induced psoriasis in a patient with atopic dermatitis successfully treated with Upadacitinib: A case report"],"prefix":"10.1177","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5439-228X","authenticated-orcid":false,"given":"Katrina D","family":"Cirone","sequence":"first","affiliation":[{"name":"Schulich School of Medicine & Dentistry, Western University, London, ON, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6994-717X","authenticated-orcid":false,"given":"Fiona E","family":"Lovegrove","sequence":"additional","affiliation":[{"name":"Schulich School of Medicine & Dentistry, Western University, London, ON, Canada"},{"name":"Lovegrove Dermatology, London, ON, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2025,2,3]]},"reference":[{"key":"bibr1-2050313X251317811","doi-asserted-by":"publisher","DOI":"10.2500\/aap.2019.40.4202"},{"key":"bibr2-2050313X251317811","doi-asserted-by":"publisher","DOI":"10.4168\/aair.2012.4.1.12"},{"key":"bibr3-2050313X251317811","doi-asserted-by":"publisher","DOI":"10.1007\/s40257-017-0324-7"},{"key":"bibr4-2050313X251317811","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(15)00388-8"},{"key":"bibr5-2050313X251317811","doi-asserted-by":"publisher","DOI":"10.1159\/000530608"},{"key":"bibr6-2050313X251317811","doi-asserted-by":"publisher","DOI":"10.1080\/14740338.2024.2326480"},{"key":"bibr7-2050313X251317811","doi-asserted-by":"publisher","DOI":"10.1016\/j.coi.2017.08.008"},{"key":"bibr8-2050313X251317811","doi-asserted-by":"publisher","DOI":"10.1001\/jamadermatol.2021.3023"},{"key":"bibr9-2050313X251317811","doi-asserted-by":"publisher","DOI":"10.1007\/s40744-021-00305-z"},{"key":"bibr10-2050313X251317811","doi-asserted-by":"publisher","DOI":"10.1080\/09546634.2023.2183729"},{"key":"bibr11-2050313X251317811","doi-asserted-by":"publisher","DOI":"10.1136\/rmdopen-2020-001374"},{"key":"bibr12-2050313X251317811","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.14673"},{"key":"bibr13-2050313X251317811","doi-asserted-by":"publisher","DOI":"10.1007\/s40265-020-01283-2"},{"key":"bibr14-2050313X251317811","doi-asserted-by":"publisher","DOI":"10.1097\/DER.0000000000000481"},{"key":"bibr15-2050313X251317811","doi-asserted-by":"publisher","DOI":"10.1016\/j.jdcr.2020.01.012"},{"key":"bibr16-2050313X251317811","doi-asserted-by":"publisher","DOI":"10.1007\/s40268-022-00396-1"},{"key":"bibr17-2050313X251317811","doi-asserted-by":"publisher","DOI":"10.1111\/dth.15255"}],"container-title":["SAGE Open Medical Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/2050313X251317811","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/2050313X251317811","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/2050313X251317811","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,2,28]],"date-time":"2025-02-28T19:34:40Z","timestamp":1740771280000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/2050313X251317811"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,1]]},"references-count":17,"alternative-id":["10.1177\/2050313X251317811"],"URL":"https:\/\/doi.org\/10.1177\/2050313x251317811","relation":{},"ISSN":["2050-313X","2050-313X"],"issn-type":[{"value":"2050-313X","type":"print"},{"value":"2050-313X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,1]]},"article-number":"2050313X251317811"}}