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Few studies have investigated the involvement of key cytokines targeted by these novel therapies (interleukins 23 and 17) in the immune response against T. gondii. We describe a case of a patient with severe plaque psoriasis and a history of frequent ocular toxoplasmosis reactivations successfully treated using anti-IL-23 therapy without T. gondii reactivation. A brief scoping review of the literature is presented to address current data on toxoplasmosis and biologic therapy for psoriasis. <\/jats:p>","DOI":"10.1177\/2050313x251320196","type":"journal-article","created":{"date-parts":[[2025,2,18]],"date-time":"2025-02-18T11:16:56Z","timestamp":1739877416000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["IL-23 blockade in a patient with psoriasis and <i>Toxoplasma gondii<\/i> reactivation history: Case report and review"],"prefix":"10.1177","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0009-0006-9184-3178","authenticated-orcid":false,"given":"J.","family":"Dagher","sequence":"first","affiliation":[{"name":"CHU de Qu\u00e9bec Research Centre, Quebec City, QC, Canada"},{"name":"Faculty of Medicine, Universit\u00e9 Laval, Quebec City, QC, Canada"},{"name":"Mailman School of Public Health, Columbia University, New York City, NY, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6773-4645","authenticated-orcid":false,"given":"J.","family":"Ringuet","sequence":"additional","affiliation":[{"name":"Centre de Recherche Dermatologique de Qu\u00e9bec, Quebec City, QC, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2025,2,18]]},"reference":[{"key":"bibr1-2050313X251320196","doi-asserted-by":"publisher","DOI":"10.1007\/s40257-017-0328-3"},{"key":"bibr2-2050313X251320196","doi-asserted-by":"publisher","DOI":"10.1001\/jamadermatol.2021.2599"},{"key":"bibr3-2050313X251320196","doi-asserted-by":"publisher","DOI":"10.1016\/j.autrev.2015.01.011"},{"key":"bibr4-2050313X251320196","doi-asserted-by":"publisher","DOI":"10.1177\/03000605231175547"},{"key":"bibr5-2050313X251320196","doi-asserted-by":"publisher","DOI":"10.1007\/s10792-021-01994-9"},{"key":"bibr6-2050313X251320196","doi-asserted-by":"publisher","DOI":"10.2169\/internalmedicine.54.3977"},{"key":"bibr7-2050313X251320196","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciu185"},{"key":"bibr8-2050313X251320196","doi-asserted-by":"publisher","DOI":"10.1136\/bcr-2019-230415"},{"key":"bibr9-2050313X251320196","doi-asserted-by":"publisher","DOI":"10.1111\/ced.14198"},{"key":"bibr10-2050313X251320196","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2015.07.002"},{"key":"bibr11-2050313X251320196","unstructured":"Janssen. 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