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We present a case of a 33-year-old male patient who was diagnosed with Takayasu arteritis after being admitted for acute cardiogenic shock requiring inotropes. Initial transthoracic echocardiography demonstrated severe biventricular dysfunction. Computed tomography imaging of his chest showed pulmonary infarcts. Patient subsequently developed sudden lower extremity weakness and bowel incontinence, and urgent magnetic resonance imaging of his spine demonstrated thoracolumbar vascular myelopathy. Transesophageal echocardiography revealed diffuse symmetrical thickening of the walls of the aorta; findings suggestive of aortitis. Patient was initiated on intravenous corticosteroid and systemic anticoagulation. Subsequent computed tomography angiography demonstrated irregular luminal contour of the aortic arch, and complete occlusion of the left subclavian artery, abdominal aorta, superior mesenteric artery, and left renal artery. He underwent an emergent aortoiliac thrombectomy. He was transitioned to oral prednisone, tocilizumab, and azathioprine with excellent recovery.<\/jats:p>","DOI":"10.1177\/2050313x251335205","type":"journal-article","created":{"date-parts":[[2025,4,29]],"date-time":"2025-04-29T07:31:52Z","timestamp":1745911912000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["From door to diagnosis: A case report of a rare and life-threatening presentation of Takayasu arteritis"],"prefix":"10.1177","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4708-0039","authenticated-orcid":false,"given":"Eiad","family":"Habib","sequence":"first","affiliation":[{"name":"Department of Cardiovascular Medicine, Mayo Clinic Hospital, Phoenix, AZ, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laura","family":"MacPhee","sequence":"additional","affiliation":[{"name":"Department of Critical Care Medicine, Mayo Clinic Hospital, Phoenix, AZ, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fawad","family":"Aslam","sequence":"additional","affiliation":[{"name":"Department of Rheumatology, Mayo Clinic Hospital, Phoenix, AZ, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bhavesh","family":"Patel","sequence":"additional","affiliation":[{"name":"Department of Critical Care Medicine, Mayo Clinic Hospital, Phoenix, AZ, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ayan","family":"Sen","sequence":"additional","affiliation":[{"name":"Department of Critical Care Medicine, Mayo Clinic Hospital, Phoenix, AZ, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lisa","family":"LeMond","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine, Mayo Clinic Hospital, Phoenix, AZ, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ina","family":"Soh","sequence":"additional","affiliation":[{"name":"Department of Vascular Surgery, Mayo Clinic Hospital, Phoenix, AZ, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chelsea","family":"Marshall","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine, Honor Health, Phoenix, AZ, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marie","family":"Grill","sequence":"additional","affiliation":[{"name":"Department of Neurology, Mayo Clinic Hospital, Phoenix, AZ, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kartik","family":"Mangipudi","sequence":"additional","affiliation":[{"name":"Department of Neurology, University of Florida, Jacksonville, FL, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nolan","family":"McBride","sequence":"additional","affiliation":[{"name":"Department of Rheumatology, Mayo Clinic Hospital, Phoenix, AZ, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroshi","family":"Sekiguchi","sequence":"additional","affiliation":[{"name":"Department of Critical Care Medicine, Mayo Clinic Hospital, Phoenix, AZ, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2025,4,29]]},"reference":[{"key":"e_1_3_2_2_2","first-page":"20221213","article-title":"Takayasu arteritis: JACC focus seminar 3\/4","volume":"81","author":"Joseph G","year":"2022","unstructured":"Joseph G, Goel R, Thomson VS, et al. Takayasu arteritis: JACC focus seminar 3\/4. 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