{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,6]],"date-time":"2026-01-06T05:29:00Z","timestamp":1767677340148,"version":"3.48.0"},"reference-count":28,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2025,5,24]],"date-time":"2025-05-24T00:00:00Z","timestamp":1748044800000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,5,24]],"date-time":"2025-05-24T00:00:00Z","timestamp":1748044800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Sage Open Medical Case Reports"],"published-print":{"date-parts":[[2025,12]]},"abstract":"<jats:p>Antidepressant discontinuation syndrome is commonly observed among patients who abruptly discontinue or reduce the dosage of an antidepressant that has been administered for at least 6 weeks. Common manifestations may include flu-like symptoms, insomnia, nausea, impaired balance, sensory disturbances, headache, irritability, anxiety, and hyperarousal. These symptoms are typically mild, persist for 1\u20132 weeks, and resolve upon resumption of the medication. The probability of developing this syndrome increases with the prescribed pharmacological agent\u2019s prolonged treatment duration and shorter half-life. Before prescribing antidepressants, it is imperative to inform patients about the potential complications associated with the sudden discontinuation of the medication. Understanding this phenomenon can help prevent future incidents and reduce nonadherence risk. The majority of antidepressants possess the potential to induce antidepressant discontinuation syndrome. This case report presents a unique instance of discontinuation syndrome in a 50-year-old female patient with major depressive disorder who had been effectively managed on desvenlafaxine for several years. After initiating domperidone for chemotherapy-induced nausea, she experienced \u201cbrain zaps\u201d and other symptoms consistent with antidepressant discontinuation syndrome. Upon cessation of domperidone, her symptoms rapidly resolved. This report examines potential interactions between domperidone and desvenlafaxine, emphasizing the necessity for clinicians to be cognizant of possible drug interactions that may precipitate discontinuation symptoms.<\/jats:p>","DOI":"10.1177\/2050313x251342973","type":"journal-article","created":{"date-parts":[[2025,5,25]],"date-time":"2025-05-25T02:12:47Z","timestamp":1748139167000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":1,"title":["A rare case of antidepressant discontinuation syndrome triggered by domperidone: Clinical insights and literature review"],"prefix":"10.1177","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0009-0002-4586-8965","authenticated-orcid":false,"given":"Ashour","family":"Barkho","sequence":"first","affiliation":[{"name":"Department of Pharmacy, London Health Sciences Centre, ON, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0803-1138","authenticated-orcid":false,"given":"Bushra","family":"Elhusein","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, London Health Sciences Centre, ON, Canada"},{"name":"Assistant Professor of Psychiatry, Schulich School of Medicine and Dentistry, University of Western Ontario, London, ON, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Niman","family":"Gajebasia","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, London Health Sciences Centre, ON, Canada"},{"name":"Assistant Professor of Psychiatry, Schulich School of Medicine and Dentistry, University of Western Ontario, London, ON, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2025,5,24]]},"reference":[{"issue":"20","key":"e_1_3_2_2_2","first-page":"355","article-title":"Antidepressant withdrawal and rebound phenomena","volume":"116","author":"Henssler J","year":"2019","unstructured":"Henssler J, Heinz A, Brandt L, et al. 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