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We present the case of a 27-year-old female diagnosed with malignant right fibula myoepithelial tumor\/myoepithelial carcinoma, initially treated with systemic chemotherapy. During treatment, she developed uncontrolled leg pain and metastatic disease to the lungs, leading to a palliative above-knee amputation. Due to the rarity of malignant myoepithelial tumors and the lack of treatment guidelines, a systematic literature review was conducted, exploring various chemotherapeutic and biological agents. Her treatment was planned by a multidisciplinary team, considering her willingness to continue treatment, and ultimately, a decision was made to proceed with palliative care. This case report aims to provide valuable insights for physicians managing patients with this rare diagnosis.<\/jats:p>","DOI":"10.1177\/2050313x251342989","type":"journal-article","created":{"date-parts":[[2025,5,25]],"date-time":"2025-05-25T02:15:17Z","timestamp":1748139317000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Malignant myoepithelial tumor of the right fibula in a young female: A case report"],"prefix":"10.1177","volume":"13","author":[{"given":"Tasneem","family":"AbuShaikha","sequence":"first","affiliation":[{"name":"Faculty of Medicine, Al-Quds University, Abu-Dis, Palestine"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Saja","family":"Alzboun","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Al-Quds University, Abu-Dis, Palestine"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ameer","family":"Alhosheyeh","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Al-Quds University, Abu-Dis, Palestine"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Imad","family":"Aljaafreh","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Al-Quds University, Abu-Dis, Palestine"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ahmad","family":"Alhalabia","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Al-Quds University, Abu-Dis, Palestine"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Haytham","family":"Shaban","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Al-Quds University, Abu-Dis, Palestine"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ahmed","family":"Barbarawi","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Al-Quds University, Abu-Dis, Palestine"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yazan","family":"Haddar","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Al-Quds University, Abu-Dis, Palestine"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Farah","family":"Awad","sequence":"additional","affiliation":[{"name":"Department of Oncology, Augusta Victoria Hospital, East Jerusalem, Palestinian Authority, Palestine"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6514-5206","authenticated-orcid":false,"given":"Elias Edward","family":"Lahham","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, Augusta Victoria Hospital, East Jerusalem, Palestinian Authority, Palestine"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2025,5,24]]},"reference":[{"key":"e_1_3_3_2_2","article-title":"Myoepithelioma of minor salivary gland origin. 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