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Despite multiple endoscopy and imaging examinations, the source of bleeding remained elusive. The patient ultimately underwent exploratory laparotomy with splenectomy, which revealed a Meckel\u2019s diverticulum with stale hemorrhage, along with congestive changes in the spleen. Following surgery, the patient experienced a complete resolution of symptoms with normalization of hematological parameters. This case highlights Meckel\u2019s diverticulum as a rare cause of obscure gastrointestinal bleeding, with the unique presentation of splenomegaly due to extramedullary hematopoiesis.<\/jats:p>","DOI":"10.1177\/2050313x251351454","type":"journal-article","created":{"date-parts":[[2025,6,27]],"date-time":"2025-06-27T07:07:27Z","timestamp":1751008047000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["A unique case of gastrointestinal bleeding with splenomegaly"],"prefix":"10.1177","volume":"13","author":[{"given":"Can","family":"Gan","sequence":"first","affiliation":[{"name":"Department of Gastroenterology, West China Hospital, Sichuan University, Chengdu, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3488-2246","authenticated-orcid":false,"given":"Shihang","family":"Tang","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Chongqing University Cancer Hospital, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2025,6,27]]},"reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.20452\/pamw.16253"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000012154"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.12998\/wjcc.v6.i14.791"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.suc.2023.12.001"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.5009\/gnl16552"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1097\/TA.0000000000002300"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jviscsurg.2017.06.006"},{"key":"e_1_3_2_9_2","article-title":"A case of obscure gastrointestinal bleeding in a 18-year-old woman","volume":"85","author":"La Rocca F","year":"2014","unstructured":"La Rocca F, Molino C, Petrocelli M, et al. 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