{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,6]],"date-time":"2026-01-06T05:28:31Z","timestamp":1767677311931,"version":"3.48.0"},"reference-count":20,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2025,7,16]],"date-time":"2025-07-16T00:00:00Z","timestamp":1752624000000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2025,7,16]],"date-time":"2025-07-16T00:00:00Z","timestamp":1752624000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Sage Open Medical Case Reports"],"published-print":{"date-parts":[[2025,12]]},"abstract":"<jats:p>\n                    Congenital syphilis remains a preventable cause of neonatal morbidity, often resulting from undiagnosed or untreated maternal infection. We report a case of a late-preterm infant born to a mother with late latent syphilis underdiagnosed during pregnancy. Vertical transmission occurred transplacentally, given that the neonate presented with respiratory distress and pathognomonic signs such as pemphigus on both feet at birth. Laboratory evaluation confirmed syphilis infection, with high titer of RPR (Rapid Plasma Reagin) and TPHA (\n                    <jats:italic toggle=\"yes\">Treponema Pallidum<\/jats:italic>\n                    Hemagglutination Assay) and markedly elevated inflammatory markers. The infant received a 10-day course of intravenous penicillin, leading to rapid clinical improvement and resolution of skin lesions. Serial serological monitoring showed a steady decline in RPR titers, achieving seronegativity by 6 months, accompanied by catch-up growth by 1 year. This case underscores the importance of thorough antenatal screening, early diagnosis, and treatment of maternal syphilis, and comprehensive management and follow-up of infected infants, particularly in resource-limited settings as Cambodia.\n                  <\/jats:p>","DOI":"10.1177\/2050313x251358975","type":"journal-article","created":{"date-parts":[[2025,7,16]],"date-time":"2025-07-16T08:14:20Z","timestamp":1752653660000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["A case report of congenital pemphigus syphiliticus in a preterm neonate: Insights into diagnosis, treatment, and long-term follow-up in a resource-limited country (Cambodia)"],"prefix":"10.1177","volume":"13","author":[{"given":"Bormey","family":"Sim","sequence":"first","affiliation":[{"name":"Neonatal Intensive Care Unit, Calmette Hospital, Phnom Penh, Cambodia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vuthny","family":"Din","sequence":"additional","affiliation":[{"name":"University of Health Sciences, Phnom Penh, Cambodia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sethikar","family":"Im","sequence":"additional","affiliation":[{"name":"Neonatal Intensive Care Unit, Calmette Hospital, Phnom Penh, Cambodia"},{"name":"Ministry of Health Sciences, Phnom Penh, Cambodia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2513-8690","authenticated-orcid":false,"given":"Sakviseth","family":"Bin","sequence":"additional","affiliation":[{"name":"Neonatal Intensive Care Unit, Calmette Hospital, Phnom Penh, Cambodia"},{"name":"University of Health Sciences, Phnom Penh, Cambodia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2025,7,16]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1128\/cmr.00126-22"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1071\/SH14174"},{"key":"e_1_3_3_4_2","article-title":"Global burden of maternal and congenital syphilis and associated adverse birth outcomes\u2014estimates for 2016 and progress since 2012","volume":"14","author":"Korenromp EL","year":"2019","unstructured":"Korenromp EL, Rowley J, Alonso M, et al. Global burden of maternal and congenital syphilis and associated adverse birth outcomes\u2014estimates for 2016 and progress since 2012. PLoS One 2019; 14: e0211720.","journal-title":"PLoS One"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.7189\/jogh.10.010504"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1111\/tmi.13881"},{"key":"e_1_3_3_7_2","unstructured":"Leslie SW Vaidya R. Congenital and maternal syphilis. StatPearls https:\/\/www.ncbi.nlm.nih.gov\/books\/NBK537087\/ (2025 accessed 21 April 2025)."},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1136\/bcr-2021-246310"},{"issue":"3","key":"e_1_3_3_9_2","article-title":"Congenital syphilis: a case report presenting a rare clinical manifestation in two-month-old newborn in Bahrain","volume":"16","author":"Maqwar ZB","year":"2024","unstructured":"Maqwar ZB, Alalawi AS. Congenital syphilis: a case report presenting a rare clinical manifestation in two-month-old newborn in Bahrain. Cureus 2024; 16(3): e56005_","journal-title":"Cureus"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.3390\/children10081310"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1097\/ANC.0000000000000534"},{"key":"e_1_3_3_12_2","volume-title":"Red Book: 2024-2027 Report of the Committee on Infectious Diseases","author":"Kimberlin DW","year":"2024","unstructured":"Kimberlin DW, Banerjee R, Barnett E, et al. Red Book: 2024-2027 Report of the Committee on Infectious Diseases. Itasca, IL: American Academy of Pediatrics, 2024."},{"issue":"4","key":"e_1_3_3_13_2","first-page":"1","article-title":"Sexually transmitted infections treatment guidelines, 2021","volume":"70","author":"Walensky RP","year":"2021","unstructured":"Walensky RP, Jernigan DB, Bunnell R, et al. Sexually transmitted infections treatment guidelines, 2021. 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