{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,21]],"date-time":"2025-08-21T17:48:47Z","timestamp":1755798527012,"version":"3.44.0"},"reference-count":18,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["SAGE Open Medical Case Reports"],"published-print":{"date-parts":[[2025,8]]},"abstract":"<jats:p>Propofol is a commonly used sedative for the induction of clinical anesthesia and sedation maintenance in intensive care unit patients. However, in a minority of patients, prolonged infusion of propofol may cause metabolic acidosis, electrocardiographic abnormalities, arrhythmias, and rhabdomyolysis, a condition known as propofol-related infusion syndrome. If not promptly identified and managed, propofol-related infusion syndrome can be fatal. Propofol-related infusion syndrome typically occurs in critically ill patients in the intensive care unit and is less common in clinical surgical anesthesia. We herein report a case of a patient with hematospermia who developed propofol-related infusion syndrome perioperatively, receiving a large amount of propofol infusion in a short time due to agitation during anesthesia recovery. Arterial blood gas analysis indicated persistently increasing lactic acid and unresolving metabolic acidosis, leading to the patient\u2019s transfer to the intensive care unit for further treatment. During intensive care unit treatment, the patient received continuous propofol infusion for sedation, with doses reaching up to 10\u2009\u03bcg\/kg\/min, and a total infusion duration of ~8\u2009h. We highly suspected propofol-related infusion syndrome and discontinued propofol. The patient successfully recovered after continuous renal replacement therapy. Propofol-related infusion syndrome can occur in non-critically ill patients receiving short-term propofol; hence, caution is warranted when using this drug. Early blood purification therapy is recommended for a better recovery from propofol-related infusion syndrome, and alternative sedatives should be considered as needed.<\/jats:p>","DOI":"10.1177\/2050313x251359394","type":"journal-article","created":{"date-parts":[[2025,8,19]],"date-time":"2025-08-19T09:26:32Z","timestamp":1755595592000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Propofol-related infusion syndrome happened in a non-critically ill perioperative young patient: A case report"],"prefix":"10.1177","volume":"13","author":[{"given":"Haibo","family":"Zhang","sequence":"first","affiliation":[{"name":"Department of Critical Medicine, Xi\u2019an Daxing Hospital, Yan\u2019an University, Shaanxi, People\u2019s Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6155-1998","authenticated-orcid":false,"given":"Yezu","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Peking University People\u2019s Hospital, Peking University, Beijing, People\u2019s Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Minlong","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Critical Medicine, Xi\u2019an Daxing Hospital, Yan\u2019an University, Shaanxi, People\u2019s Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bing","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Critical Medicine, Xi\u2019an Daxing Hospital, Yan\u2019an University, Shaanxi, People\u2019s Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Haima","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, The Nuclear Industry 215 Hospital of Shaanxi Province, Xianyang, Shaanxi, People\u2019s Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2025,8,19]]},"reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.hrthm.2005.12.002"},{"key":"e_1_3_2_3_2","first-page":"260385","article-title":"Propofol infusion syndrome in adults: a clinical update","volume":"2015","author":"Mirrakhimov AE","year":"2015","unstructured":"Mirrakhimov AE, Voore P, Halytskyy O, et al. Propofol infusion syndrome in adults: a clinical update. Crit Care Res Pract 2015; 2015: 260385.","journal-title":"Crit Care Res Pract"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bja.2018.12.025"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(99)90018-1"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1592\/phco.28.2.250"},{"issue":"10","key":"e_1_3_2_7_2","article-title":"Propofol-related infusion syndrome: a clinical review","volume":"14","author":"Singh A","year":"2022","unstructured":"Singh A, Anjankar AP. Propofol-related infusion syndrome: a clinical review. Cureus 2022; 14(10): e30383.","journal-title":"Cureus"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1186\/cc8145"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.2165\/00002018-200831040-00003"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1177\/0883073816661458"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1002\/ams2.473"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0b013e3182a1aa78"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000542-200503000-00042"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.283.5407.1482"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa031314"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.4266\/acc.2021.00829"},{"issue":"10","key":"e_1_3_2_17_2","article-title":"Propofol-related infusion syndrome in a child with refractory status epilepticus: successful resuscitation with veno-arterial extracorporeal membrane oxygenation, continuous renal replacement therapy, and therapeutic plasma exchange","volume":"15","author":"Calvano J","year":"2023","unstructured":"Calvano J, Paluska MR, Armijo AJ, et al. Propofol-related infusion syndrome in a child with refractory status epilepticus: successful resuscitation with veno-arterial extracorporeal membrane oxygenation, continuous renal replacement therapy, and therapeutic plasma exchange. Cureus 2023; 15(10): e47866.","journal-title":"Cureus"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.1186\/s13054-016-1364-8"},{"key":"e_1_3_2_19_2","doi-asserted-by":"publisher","DOI":"10.1186\/2110-5820-3-32"}],"container-title":["SAGE Open Medical Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/2050313X251359394","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/2050313X251359394","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/2050313X251359394","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,21]],"date-time":"2025-08-21T13:37:46Z","timestamp":1755783466000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/2050313X251359394"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,8]]},"references-count":18,"alternative-id":["10.1177\/2050313X251359394"],"URL":"https:\/\/doi.org\/10.1177\/2050313x251359394","relation":{},"ISSN":["2050-313X","2050-313X"],"issn-type":[{"type":"print","value":"2050-313X"},{"type":"electronic","value":"2050-313X"}],"subject":[],"published":{"date-parts":[[2025,8]]},"article-number":"2050313X251359394"}}