{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,17]],"date-time":"2025-09-17T16:03:38Z","timestamp":1758125018379,"version":"3.44.0"},"reference-count":15,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"name":"Research Project (Task) Assignment of Shanghai Science and Technology Commission","award":["Project ID: 20Z11900600"],"award-info":[{"award-number":["Project ID: 20Z11900600"]}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["SAGE Open Medical Case Reports"],"published-print":{"date-parts":[[2025,8]]},"abstract":"<jats:p>This case report describes a rare instance of heart failure temporally associated with the administration of mydriatic eye drops during routine retinopathy of prematurity screening. A 36-week-old preterm infant developed acute tachypnea, tachycardia, and hepatomegaly shortly after receiving 0.5% tropicamide and 0.5% phenylephrine, and was subsequently diagnosed with heart failure, which responded well to intravenous deslanoside. Cardiac imaging later revealed multiple congenital anomalies, including an atrial septal defect, persistent left superior vena cava, and horseshoe lung, among others. No similar cardiovascular symptoms were observed during a subsequent screening using tropicamide alone, suggesting that phenylephrine may have contributed to the observed hemodynamic instability. This case illustrates the potential for severe cardiovascular complications associated with mydriatic agents in neonates with undiagnosed congenital heart defects. It underscores the need for individualized risk assessment, vigilant monitoring, and cautious application of mydriatic protocols to ensure patient safety in high-risk preterm populations.<\/jats:p>","DOI":"10.1177\/2050313x251365810","type":"journal-article","created":{"date-parts":[[2025,8,15]],"date-time":"2025-08-15T07:09:23Z","timestamp":1755241763000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":1,"title":["Heart failure temporally associated with tropicamide and phenylephrine eye drops in a premature infant: A case report and literature review"],"prefix":"10.1177","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0009-0000-4952-2799","authenticated-orcid":false,"given":"Xiang","family":"Li","sequence":"first","affiliation":[{"name":"Department of Neonatology, Shanghai Children\u2019s Medical Center, Shanghai Jiao Tong University School of Medicine, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiafang","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Neonatology, Shanghai Children\u2019s Medical Center, Shanghai Jiao Tong University School of Medicine, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jianhua","family":"Sun","sequence":"additional","affiliation":[{"name":"Department of Neonatology, Shanghai Children\u2019s Medical Center, Shanghai Jiao Tong University School of Medicine, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jun","family":"Bu","sequence":"additional","affiliation":[{"name":"Department of Neonatology, Shanghai Children\u2019s Medical Center, Shanghai Jiao Tong University School of Medicine, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2025,8,15]]},"reference":[{"issue":"01","key":"e_1_3_3_2_2","article-title":"Early hemodynamic effects of mydriatic eye drops in preterm infants","volume":"41","author":"Dincer E","year":"2024","unstructured":"Dincer E, Gonen I, Bornaun HA, et al. 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