{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,26]],"date-time":"2026-07-26T02:20:00Z","timestamp":1785032400728,"version":"3.55.0"},"reference-count":20,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["SAGE Open Medical Case Reports"],"published-print":{"date-parts":[[2025,8]]},"abstract":"<jats:p>Appendiceal neuroendocrine tumors are a rare subset of well-differentiated neuroendocrine tumors, comprising &lt;1% of all malignancies. Appendiceal cancer is particularly rare, affecting approximately one to two individuals per one million annually in the United States. Appendiceal neuroendocrine tumors have an estimated incidence of 7\/100,000\u2009person-years in the United States. In this report, we present the case of a 19-year-old female who arrived to the emergency department with recurrent right lower quadrant pain, unresponsive to initial management for suspected acute appendicitis, and urinary tract infection. Advanced imaging revealed an appendiceal mucocele. The patient underwent appendectomy, and histopathology confirmed a well-differentiated appendiceal neuroendocrine tumor (grade 2) with lymphovascular invasion. A subsequent right hemicolectomy identified metastatic disease in 6 out of 27 lymph nodes. Unfortunately, the patient was lost to follow-up shortly after surgery. This case underscores the diagnostic complexities of appendiceal neuroendocrine tumors, which are often incidental findings during appendectomy and may present with nonspecific or atypical symptoms. It highlights the critical role of tumor size, grade, and histopathological evaluation in guiding management decisions, as well as the importance of a multidisciplinary approach to treatment. Moreover, it emphasizes the necessity of vigilant follow-up, particularly in young patients, to address the long-term implications of this rare malignancy and improve outcomes.<\/jats:p>","DOI":"10.1177\/2050313x251369764","type":"journal-article","created":{"date-parts":[[2025,8,26]],"date-time":"2025-08-26T07:31:53Z","timestamp":1756193513000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":2,"title":["A case of appendiceal neuroendocrine tumor with metastatic spread in a young patient"],"prefix":"10.1177","volume":"13","author":[{"given":"Fariha","family":"Hasan","sequence":"first","affiliation":[{"name":"Department of Internal Medicine, Cooper University Hospital, Camden, NJ, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amir","family":"Davoodi","sequence":"additional","affiliation":[{"name":"Cooper Medical School of Rowan University, Camden, NJ, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amy","family":"Bordogna","sequence":"additional","affiliation":[{"name":"Cooper Medical School of Rowan University, Camden, NJ, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-1035-6704","authenticated-orcid":false,"given":"Shrey","family":"Dalwadi","sequence":"additional","affiliation":[{"name":"Cooper Medical School of Rowan University, Camden, NJ, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yumna","family":"Timsaal","sequence":"additional","affiliation":[{"name":"Dow University of Health Sciences, Karachi, Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Avneet","family":"Singh","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Cooper University Hospital, Camden, NJ, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexander","family":"Garcia","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Cooper University Hospital, Camden, NJ, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kim","family":"HooKim","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Cooper University Hospital, Camden, NJ, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Satyajeet","family":"Roy","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Cooper University Hospital, Camden, NJ, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2025,8,26]]},"reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.sla.0000129342.67174.67"},{"key":"e_1_3_2_3_2","unstructured":"Craig S Brenner BE. Appendicitis: practice essentials background anatomy. Medscape https:\/\/emedicine.medscape.com\/article\/773895-overview (2022 accessed 6 May 2024)."},{"issue":"5","key":"e_1_3_2_4_2","first-page":"713","article-title":"Epidemiology of neuroendocrine tumors of the appendix in the USA: a population-based national study (2014\u20132019)","volume":"34","author":"Alkhayyat M","year":"2021","unstructured":"Alkhayyat M, Saleh MA, Coronado W, et al Epidemiology of neuroendocrine tumors of the appendix in the USA: a population-based national study (2014\u20132019). Ann Gastroenterol 2021; 34(5): 713\u2013720.","journal-title":"Ann Gastroenterol"},{"key":"e_1_3_2_5_2","unstructured":"Menon G Karanchi H. Gastrointestinal Neuroendocrine Tumors. [Updated 2025 May 23]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2025. Available from: https:\/\/www.ncbi.nlm.nih.gov\/books\/NBK448101\/."},{"key":"e_1_3_2_6_2","unstructured":"National Cancer Institute. Rare digestive system tumors: appendiceal cancer. Pediatric and Adult Rare Tumor Program National Cancer Institute https:\/\/www.cancer.gov\/pediatric-adult-rare-tumor\/rare-tumors\/rare-digestive-system-tumors\/appendiceal-cancer (2023 accessed 3 January 2025)."},{"key":"e_1_3_2_7_2","unstructured":"Moffitt Cancer Center. Types of appendix cancer. Moffitt Cancer Center (n.d.) https:\/\/www.moffitt.org\/cancers\/appendiceal-appendix-cancer\/diagnosis\/types\/#:~:text=Approximately%2050%25%20of%20all%20appendix procedure%20performed%20for%20another%20reason (accessed 3 January 2025)."},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1634\/theoncologist.2008-0207"},{"key":"e_1_3_2_9_2","unstructured":"MOFFITT Cancer Center. Carcinoid tumor appendix symptoms & treatment https:\/\/www.moffitt.org\/cancers\/gastrointestinal-carcinoid-tumor\/diagnosis\/appendix\/# (2020 accessed 12 July 2024)."},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejso.2020.09.012"},{"issue":"2","key":"e_1_3_2_11_2","article-title":"Benign or by chance: a case report on incidental appendectomy revealing a neuroendocrine tumor during traumatic exploratory laparotomy","volume":"16","author":"Douglass MB","year":"2024","unstructured":"Douglass MB, Carpenter SL, Campbell CH, et al Benign or by chance: a case report on incidental appendectomy revealing a neuroendocrine tumor during traumatic exploratory laparotomy. Cureus 2024; 16(2): e54527.","journal-title":"Cureus"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1093\/jscr\/rjz086"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.3390\/cancers15010295"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11864-023-01093-0"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12957-023-03025-6"},{"issue":"12","key":"e_1_3_2_16_2","article-title":"Prevalence of neuroendocrine tumours (NET) in patients undergoing appendicectomy for acute appendicitis: a tertiary care study","volume":"15","author":"Gobishangar S","year":"2023","unstructured":"Gobishangar S, Gobinath S, Thevamirtha C, et al Prevalence of neuroendocrine tumours (NET) in patients undergoing appendicectomy for acute appendicitis: a tertiary care study. 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