{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,23]],"date-time":"2025-09-23T02:14:53Z","timestamp":1758593693703,"version":"3.44.0"},"reference-count":11,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["SAGE Open Medical Case Reports"],"published-print":{"date-parts":[[2025,8]]},"abstract":"<jats:p>Granulomatosis with polyangiitis is a rare autoimmune disorder. Granulomatosis with polyangiitis\u2019s signs and symptoms reflect affected organs, which are inclined toward the respiratory tract and kidneys. Gastrointestinal involvement is uncommon and barely represents this disease, particularly as an initial presentation. Here, we describe a diagnostically challenging case of a 14-year-old boy whose first manifestation of granulomatosis with polyangiitis was gastrointestinal bleeding, initially resembling immunoglobulin A vasculitis. Despite overlapping features such as arthralgia and skin lesions, renal biopsy, and cytoplasmic antineutrophil cytoplasmic antibodies positivity distinctly established granulomatosis with polyangiitis diagnosis. Recognizing gastrointestinal manifestations as potential indicators of granulomatosis with polyangiitis, even when hallmark respiratory symptoms are absent, enhances vigilance, and is crucial for early diagnosis and appropriate management.<\/jats:p>","DOI":"10.1177\/2050313x251371985","type":"journal-article","created":{"date-parts":[[2025,9,18]],"date-time":"2025-09-18T08:33:45Z","timestamp":1758184425000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Gastrointestinal bleeding as an early presentation of the pediatric granulomatosis with polyangiitis: A rare report"],"prefix":"10.1177","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7001-6794","authenticated-orcid":false,"given":"Mohsen","family":"Jari","sequence":"first","affiliation":[{"name":"Department of Pediatric Rheumatology, Imam Hossein Children\u2019s Hospital, Isfahan University of Medical Sciences, Iran"},{"name":"Child Growth and Development Research Center, Research Institute for Primordial Prevention of Non-Communicable Disease, Isfahan University of Medical Sciences, Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hootan","family":"Asgari Marnani","sequence":"additional","affiliation":[{"name":"Faculty of Medical Sciences, Islamic Azad University, Najafabad Branch, Iran"},{"name":"Faculty of Medical Sciences, Isfahan University of Medical Sciences, Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Narges","family":"Chatraei","sequence":"additional","affiliation":[{"name":"Student Research Committee, Isfahan University of Medical Sciences, Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2025,9,18]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jbspin.2020.06.005"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.37715"},{"key":"e_1_3_3_4_2","article-title":"Conjunctivitis as the important indicator of pediatric granulomatosis with polyangiitis","volume":"10","author":"Jari M","year":"2022","unstructured":"Jari M, Rastinmaram Z, Niazi E, et al Conjunctivitis as the important indicator of pediatric granulomatosis with polyangiitis. SAGE Open Med Case Rep 2022; 10: 2050313X221114727.","journal-title":"SAGE Open Med Case Rep"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780330809"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2021-221795"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1590\/2175-8239-jbn-2022-e002"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.2147\/JIR.S284768"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.40577"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12876-021-01730-8"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1080\/00325481.2018.1503920"},{"issue":"1","key":"e_1_3_3_12_2","first-page":"18","article-title":"Presentation and outcomes of childhood-onset granulomatosis with polyangiitis (Wegener\u2019s): a Pediatric Vasculitis initiative (PedVas) study","volume":"14","author":"Cabral DA","year":"2016","unstructured":"Cabral DA, Canter DL, Muscal E, et al Presentation and outcomes of childhood-onset granulomatosis with polyangiitis (Wegener\u2019s): a Pediatric Vasculitis initiative (PedVas) study. Pediatr Rheumatol 2016; 14(1): 18.","journal-title":"Pediatr Rheumatol"}],"container-title":["SAGE Open Medical Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/2050313X251371985","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/2050313X251371985","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/2050313X251371985","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,9,22]],"date-time":"2025-09-22T07:13:52Z","timestamp":1758525232000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/2050313X251371985"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,8]]},"references-count":11,"alternative-id":["10.1177\/2050313X251371985"],"URL":"https:\/\/doi.org\/10.1177\/2050313x251371985","relation":{},"ISSN":["2050-313X","2050-313X"],"issn-type":[{"type":"print","value":"2050-313X"},{"type":"electronic","value":"2050-313X"}],"subject":[],"published":{"date-parts":[[2025,8]]},"article-number":"2050313X251371985"}}