{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,25]],"date-time":"2026-10-25T12:18:51Z","timestamp":1792930731255,"version":"4.5.0"},"reference-count":5,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["SAGE Open Medical Case Reports"],"published-print":{"date-parts":[[2025,8]]},"abstract":"<jats:p>Sj\u00f6gren\u2019s syndrome is a chronic autoimmune disorder with limited therapeutic options. Glucagon-like peptide-1 (GLP-1) receptor agonists, primarily used for diabetes and obesity, have emerging evidence of anti-inflammatory and immunomodulatory effects. We present a case of a 37-year-old woman with primary Sj\u00f6gren\u2019s syndrome and comorbid Hashimoto\u2019s thyroiditis and seronegative rheumatoid arthritis, who experienced frequent debilitating flares affecting her quality of life. After starting semaglutide for weight management and losing over 100\u2009lbs, the patient reported a dramatic reduction in flare frequency and duration, with episodes decreasing from multi-week flares to approximately a single day. This case suggests that semaglutide may offer dual benefits in Sj\u00f6gren\u2019s syndrome by combining substantial weight reduction with possible direct immunomodulatory effects. Further research is warranted to explore GLP-1 agonists as adjunctive therapy in the management of autoimmune diseases.<\/jats:p>","DOI":"10.1177\/2050313x251372813","type":"journal-article","created":{"date-parts":[[2025,8,31]],"date-time":"2025-08-31T07:59:30Z","timestamp":1756627170000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":3,"title":["Semaglutide as a potential therapeutic adjunct for reducing flare-ups in Sj\u00f6gren\u2019s syndrome: A case report"],"prefix":"10.1177","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0009-0006-3395-3432","authenticated-orcid":false,"given":"John","family":"Jung","sequence":"first","affiliation":[{"name":"John Sealy School of Medicine, The University of Texas Medical Branch, Galveston, TX, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ismail","family":"Zazay","sequence":"additional","affiliation":[{"name":"John Sealy School of Medicine, The University of Texas Medical Branch, Galveston, TX, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Priya","family":"Kalia","sequence":"additional","affiliation":[{"name":"Department of Family Medicine, The University of Texas Medical Branch, Galveston, TX, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Neda","family":"Shaghaghi","sequence":"additional","affiliation":[{"name":"Department of Family Medicine, The University of Texas Medical Branch, Galveston, TX, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nancy","family":"Ross","sequence":"additional","affiliation":[{"name":"Department of Family Medicine, The University of Texas Medical Branch, Galveston, TX, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benjamin","family":"Homan","sequence":"additional","affiliation":[{"name":"Department of Family Medicine, The University of Texas Medical Branch, Galveston, TX, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2025,8,31]]},"reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.3899\/jrheum.2024-1048"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1155\/2016\/3094642"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2022.997578"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1097\/RHU.0000000000001949"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.42540"}],"container-title":["SAGE Open Medical Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/2050313X251372813","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/2050313X251372813","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/2050313X251372813","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,9,3]],"date-time":"2025-09-03T01:22:32Z","timestamp":1756862552000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/2050313X251372813"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,8]]},"references-count":5,"alternative-id":["10.1177\/2050313X251372813"],"URL":"https:\/\/doi.org\/10.1177\/2050313x251372813","relation":{},"ISSN":["2050-313X","2050-313X"],"issn-type":[{"value":"2050-313X","type":"print"},{"value":"2050-313X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,8]]},"article-number":"2050313X251372813"}}