{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,23]],"date-time":"2025-12-23T05:27:27Z","timestamp":1766467647889,"version":"build-2065373602"},"reference-count":13,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Sage Open Medical Case Reports"],"published-print":{"date-parts":[[2025,10]]},"abstract":"<jats:p>Metamizole (dipyrone) is a non-opioid analgesic and antipyretic agent belonging to the pyrazolone class. While it is widely used in many countries due to its favourable safety profile compared to non-steroidal anti-inflammatory drugs and opioids, its use has been associated with rare but potentially life-threatening haematologic adverse effects, including neutropaenia and agranulocytosis. These complications typically occur within 6\u201314\u2009days of treatment initiation but may also arise earlier or significantly later, even after discontinuation of the drug. Given that late-onset neutropaenia after metamizole discontinuation may be underdiagnosed, we present the case of a 92-year-old woman who developed transient, likely drug-induced neutropaenia 10\u2009days later, with spontaneous haematologic recovery. The patient remained asymptomatic, with no signs of infection or evidence of inflammatory or neoplastic systemic disease.<\/jats:p>","DOI":"10.1177\/2050313x251381576","type":"journal-article","created":{"date-parts":[[2025,10,18]],"date-time":"2025-10-18T14:58:10Z","timestamp":1760799490000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":1,"title":["A probable case of metamizole-induced neutropaenia presenting 10\u2009days after drug discontinuation"],"prefix":"10.1177","volume":"13","author":[{"given":"Carola","family":"Petino","sequence":"first","affiliation":[{"name":"Clinic for Geriatric Medicine, Center for Geriatric Medicine and Rehabilitation, Bruderholz Hospital, Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marta","family":"Moreno Sol\u00e9","sequence":"additional","affiliation":[{"name":"Clinic for Geriatric Medicine, Center for Geriatric Medicine and Rehabilitation, Bruderholz Hospital, Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5298-7925","authenticated-orcid":false,"given":"Mairi","family":"Ziaka","sequence":"additional","affiliation":[{"name":"Department of Emergency Medicine, Inselspital, University Hospital Bern, University of Bern, Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2025,10,18]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1177\/20420986241275255"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1186\/s40348-023-00160-8"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1111\/bcpt.13310"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1097\/FPC.0000000000000432"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.tox.2019.152254"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bcp.2019.01.011"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejim.2019.07.029"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00482-016-0160-3"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00228-014-1777-8"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.2169\/internalmedicine.48.2093"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1182\/hematology.2021000284"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1111\/bcp.15108"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.1007\/s40272-020-00431-1"}],"container-title":["Sage Open Medical Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/2050313X251381576","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/2050313X251381576","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/2050313X251381576","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,22]],"date-time":"2025-10-22T07:15:39Z","timestamp":1761117339000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/2050313X251381576"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,10]]},"references-count":13,"alternative-id":["10.1177\/2050313X251381576"],"URL":"https:\/\/doi.org\/10.1177\/2050313x251381576","relation":{},"ISSN":["2050-313X","2050-313X"],"issn-type":[{"type":"print","value":"2050-313X"},{"type":"electronic","value":"2050-313X"}],"subject":[],"published":{"date-parts":[[2025,10]]},"article-number":"2050313X251381576"}}