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Erosive lichen planus is often resistant to therapies, and spontaneous remission is uncommon. We report the case of a 62-year-old woman with severe and refractory erosive lichen planus involving the oral, genital, and esophageal mucosa, who failed multiple systemic treatments. Initiation of abrocitinib, a selective Janus Kinase 1 inhibitor, led to complete and sustained clinical remission.<\/jats:p>","DOI":"10.1177\/2050313x251400969","type":"journal-article","created":{"date-parts":[[2025,11,28]],"date-time":"2025-11-28T06:05:32Z","timestamp":1764309932000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":1,"title":["Successful treatment of refractory erosive lichen planus with abrocitinib: A case report"],"prefix":"10.1177","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0009-0008-1430-2321","authenticated-orcid":false,"given":"Valerie","family":"Hladky","sequence":"first","affiliation":[{"name":"Faculty of Medicine, Universit\u00e9 de Montr\u00e9al, QC, Canada"},{"name":"Division of Dermatology, Department of Medicine, Center Hospitalier de l\u2019Universit\u00e9 de Montr\u00e9al, QC, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Deana","family":"Funaro","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Universit\u00e9 de Montr\u00e9al, QC, Canada"},{"name":"Division of Dermatology, Department of Medicine, Center Hospitalier de l\u2019Universit\u00e9 de Montr\u00e9al, QC, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rosalie-S\u00e9l\u00e8ne","family":"Meunier","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Universit\u00e9 de Montr\u00e9al, QC, Canada"},{"name":"Division of Internal Medicine, Department of Medicine, H\u00f4pital du Sacr\u00e9-Coeur-de-Montr\u00e9al, QC, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4090-7833","authenticated-orcid":false,"given":"Alexandra","family":"Mereniuk","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Universit\u00e9 de Montr\u00e9al, QC, Canada"},{"name":"Division of Dermatology, Department of Medicine, H\u00f4pital du Sacr\u00e9-Coeur-de-Montr\u00e9al, QC, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8906-426X","authenticated-orcid":false,"given":"Alexandre","family":"Lemieux","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Universit\u00e9 de Montr\u00e9al, QC, Canada"},{"name":"Division of Dermatology, Department of Medicine, H\u00f4pital du Sacr\u00e9-Coeur-de-Montr\u00e9al, QC, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2025,11,27]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2010.03.029"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ogc.2017.04.004"},{"key":"e_1_3_3_4_2","article-title":"Successful treatment of erosive lichen planus with Upadacitinib complicated by oral squamous cell carcinoma","volume":"11","author":"Landells FM","year":"2023","unstructured":"Landells FM, Goudie S, McGrath J, et al Successful treatment of erosive lichen planus with Upadacitinib complicated by oral squamous cell carcinoma. 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