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Various treatment options have been reported in the literature, although none are universally effective. Topical roflumilast (0.3%) is a recently approved phosphodiesterase-4 inhibitor first used in psoriasis which has shown reduction in hyperkeratosis in vitro. We report on an adult with symptomatic and recalcitrant lichen spinulosis who achieved significant improvement with the use of topical roflumilast over a 6-month period.<\/jats:p>","DOI":"10.1177\/2050313x251400983","type":"journal-article","created":{"date-parts":[[2025,12,4]],"date-time":"2025-12-04T14:14:23Z","timestamp":1764857663000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Successful treatment of lichen spinulosis with topical roflumilast: A case report"],"prefix":"10.1177","volume":"13","author":[{"given":"Rose","family":"He","sequence":"first","affiliation":[{"name":"Cumming School of Medicine, University of Calgary, AB, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yitong","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine, University of Calgary, AB, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Karen","family":"Naert","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine, University of Calgary, AB, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3072-3456","authenticated-orcid":false,"given":"Justin C.","family":"Chia","sequence":"additional","affiliation":[{"name":"Cumming School of Medicine, University of Calgary, AB, Canada"},{"name":"Division of Dermatology, University of Calgary, AB, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2025,12,4]]},"reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.143.1.122"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1684\/ejd.2015.2597"},{"key":"e_1_3_2_4_2","first-page":"20","article-title":"Lichen spinulosus: case report and review of literatures","volume":"2015","author":"Hawsawi K","year":"2015","unstructured":"Hawsawi K, Almehmadi K, Alraddadi B, et al. Lichen spinulosus: case report and review of literatures. 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