{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T20:20:48Z","timestamp":1791231648914,"version":"4.1.0"},"reference-count":4,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Sage Open Medical Case Reports"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:p>We report a rare case of Stevens\u2013Johnson syndrome\/toxic epidermal necrolysis as the initial manifestation of paraneoplastic dermatomyositis in a 50-year-old man subsequently diagnosed with diffuse large B cell lymphoma, in the absence of any identifiable drug exposure. The patient presented with periorbital edema, progressive dusky blistering eruption (Nikolsky sign positive), mucositis, and histopathology consistent with Stevens\u2013Johnson syndrome\/toxic epidermal necrolysis. Over the following weeks, he developed proximal muscle weakness, elevated creatine kinase, and cutaneous signs of dermatomyositis, including heliotrope rash and Gottron\u2019s papules, with serologic confirmation via anti-TIF1-\u03b3 antibodies. Imaging revealed a hypermetabolic axillary mass, and excisional biopsy confirmed diffuse large B cell lymphoma. This case highlights a novel presentation of Stevens\u2013Johnson syndrome\/toxic epidermal necrolysis in the setting of autoimmune and paraneoplastic immune dysregulation. It underscores the importance of considering nondrug-induced triggers in Stevens\u2013Johnson syndrome\/toxic epidermal necrolysis.<\/jats:p>","DOI":"10.1177\/2050313x251406472","type":"journal-article","created":{"date-parts":[[2026,1,14]],"date-time":"2026-01-14T13:08:34Z","timestamp":1768396114000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":1,"title":["Stevens\u2013Johnson syndrome\/toxic epidermal necrolysis as the initial presentation of paraneoplastic anti-TIF1-\u03b3 dermatomyositis"],"prefix":"10.1177","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0009-0005-4845-5770","authenticated-orcid":false,"given":"Ghassan","family":"Barnawi","sequence":"first","affiliation":[{"name":"Division of Dermatology, McGill University, Montreal, QC, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-5031-6363","authenticated-orcid":false,"given":"Raquel","family":"Lazarowitz","sequence":"additional","affiliation":[{"name":"Faculty of Medicine and Health Sciences, McGill University, Montreal, QC, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lara","family":"Al-Sabeh","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, University of Montreal, QC, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ammar","family":"Saed Aldien","sequence":"additional","affiliation":[{"name":"Faculty of Medicine and Health Sciences, McGill University, Montreal, QC, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0562-4675","authenticated-orcid":false,"given":"Ivan V.","family":"Litvinov","sequence":"additional","affiliation":[{"name":"Division of Dermatology, St. Mary\u2019s Hospital Centre, Montreal, QC, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2026,1,14]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-319-74698-2_195-1"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1111\/iwj.70117"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1111\/ced.14648"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1080\/1750743X.2024.2362107"}],"container-title":["Sage Open Medical Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/2050313X251406472","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/2050313X251406472","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/2050313X251406472","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,1,25]],"date-time":"2026-01-25T20:36:44Z","timestamp":1769373404000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/2050313X251406472"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1]]},"references-count":4,"alternative-id":["10.1177\/2050313X251406472"],"URL":"https:\/\/doi.org\/10.1177\/2050313x251406472","relation":{},"ISSN":["2050-313X","2050-313X"],"issn-type":[{"value":"2050-313X","type":"print"},{"value":"2050-313X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,1]]},"article-number":"2050313X251406472"}}