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However, in some cases, it can emerge as an adverse effect of biologic therapy, particularly interleukin-6 inhibitors such as tocilizumab. This case report describes the unexpected onset of psoriatic dermatitis in a 16-year-old male diagnosed with polyarticular juvenile idiopathic arthritis following treatment with tocilizumab. The patient had no prior personal or family history of psoriasis, highlighting a potential paradoxical reaction to interleukin-6 inhibition. Management strategies included topical corticosteroids and vitamin D analogs, with consideration of dose adjustment or transition to an alternative biologic therapy. This case highlights the importance of recognizing dermatologic adverse effects associated with interleukin-6 inhibitors and emphasizes the need for individualized treatment strategies in juvenile idiopathic arthritis patients receiving biologic therapy.<\/jats:p>","DOI":"10.1177\/2050313x251408894","type":"journal-article","created":{"date-parts":[[2026,1,7]],"date-time":"2026-01-07T11:40:17Z","timestamp":1767786017000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":2,"title":["Tocilizumab-induced psoriatic dermatitis in polyarticular juvenile idiopathic arthritis: A rare case report"],"prefix":"10.1177","volume":"14","author":[{"given":"Rahul Yedpallikar","family":"Rajesh","sequence":"first","affiliation":[{"name":"Tbilisi State Medical University, Georgia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pavisankar","family":"Biju Seena","sequence":"additional","affiliation":[{"name":"Government Medical College Manjeri, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eka","family":"Nakhutsrishvili","sequence":"additional","affiliation":[{"name":"G. 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