{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T09:35:41Z","timestamp":1791884141459,"version":"4.3.4"},"reference-count":19,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Sage Open Medical Case Reports"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:p>\n                    <jats:italic toggle=\"yes\">Aggregatibacter aphrophilus<\/jats:italic>\n                    , a fastidious Gram-negative member of the\n                    <jats:italic toggle=\"yes\">Haemophilus<\/jats:italic>\n                    ,\n                    <jats:italic toggle=\"yes\">Aggregatibacter<\/jats:italic>\n                    ,\n                    <jats:italic toggle=\"yes\">Cardiobacterium<\/jats:italic>\n                    ,\n                    <jats:italic toggle=\"yes\">Eikenella<\/jats:italic>\n                    , and\n                    <jats:italic toggle=\"yes\">Kingella<\/jats:italic>\n                    group, is an exceptionally rare cause of hepatic abscess, particularly in immunocompetent individuals. We describe a case of a healthy, middle-aged man who presented with a 5-day history of cyclical fevers, chills, and night sweats. Computed tomography imaging revealed a solitary hepatic lesion, initially suspicious for malignancy. Magnetic resonance cholangiopancreatography confirmed a hepatic abscess. Culture from a computed tomography-guided aspirate identified\n                    <jats:italic toggle=\"yes\">A. aphrophilus<\/jats:italic>\n                    as the causative organism. Despite empiric broad-spectrum antibiotics and drainage, the patient continued to experience febrile episodes until culture-directed therapy led to clinical resolution. He received 3\u2009weeks of intravenous ceftriaxone 2\u2009g q24\u2009h and PO metronidazole 500\u2009mg q8\u2009h and percutaneous drainage. Upon follow-up with infectious disease, no recurrence was noted upon review of repeat computed tomography imaging. This case highlights the importance of early microbiological identification and targeted treatment, even in healthy hosts.\n                  <\/jats:p>","DOI":"10.1177\/2050313x251409861","type":"journal-article","created":{"date-parts":[[2026,1,14]],"date-time":"2026-01-14T13:13:56Z","timestamp":1768396436000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":1,"title":["A rare case of hepatic abscess due to\n                    <i>Aggregatibacter aphrophilus<\/i>\n                    : Case report and literature review"],"prefix":"10.1177","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0009-0008-3090-9027","authenticated-orcid":false,"given":"Angela","family":"Tran","sequence":"first","affiliation":[{"name":"Penn State College of Medicine, Hershey, PA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Evelyn","family":"Marin","sequence":"additional","affiliation":[{"name":"Penn State College of Medicine, Hershey, PA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ahmad","family":"Matarneh","sequence":"additional","affiliation":[{"name":"Internal Medicine, Pennsylvania State Milton S. Hershey Medical Center, Hershey, PA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joshua","family":"Zent","sequence":"additional","affiliation":[{"name":"Internal Medicine, Pennsylvania State Milton S. Hershey Medical Center, Hershey, PA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zarish","family":"Umar","sequence":"additional","affiliation":[{"name":"Internal Medicine, Pennsylvania State Milton S. Hershey Medical Center, Hershey, PA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kunal","family":"Desai","sequence":"additional","affiliation":[{"name":"Internal Medicine, Pennsylvania State Milton S. Hershey Medical Center, Hershey, PA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2026,1,14]]},"reference":[{"issue":"10","key":"e_1_3_3_2_2","article-title":"Epidemiology, clinical features, and outcome of liver abscess: a single-center experience","volume":"14","author":"Sahu V","year":"2022","unstructured":"Sahu V, Pipal DK, Singh Y, et al. Epidemiology, clinical features, and outcome of liver abscess: a single-center experience. Cureus 2022; 14(10): e29812.","journal-title":"Cureus"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1136\/flgastro-2019-101240"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12879-024-09226-y"},{"key":"e_1_3_3_5_2","unstructured":"Akhondi H Sabih DE. Liver abscess. In: StatPearls (Internet). StatPearls Publishing https:\/\/www.ncbi.nlm.nih.gov\/books\/NBK538230\/ (2025 accessed 23 November 2025)."},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jceh.2020.10.002"},{"issue":"3","key":"e_1_3_3_7_2","first-page":"102","article-title":"Challenges and insights in Aggregatibacter aphrophilus endocarditis: a review of literature","volume":"4","author":"Zacar\u00edas Mendoza NV","year":"2023","unstructured":"Zacar\u00edas Mendoza NV, Gamarra Valverde NN, Robles Velarde VJ. Challenges and insights in Aggregatibacter aphrophilus endocarditis: a review of literature. Arch Peru Cardiol Cir Cardiovasc 2023; 4(3): 102\u2013108.","journal-title":"Arch Peru Cardiol Cir Cardiovasc"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.clineuro.2022.107337"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1186\/s13256-020-02650-z"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1186\/1752-1947-4-69"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmii.2011.12.004"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1097\/00007611-199408000-00009"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jinf.2004.07.005"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmii.2013.12.007"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.11604\/pamj.2018.31.115.16409"},{"key":"e_1_3_3_16_2","doi-asserted-by":"publisher","DOI":"10.2169\/internalmedicine.4220-19"},{"key":"e_1_3_3_17_2","doi-asserted-by":"publisher","DOI":"10.1080\/14787210.2016.1184085"},{"key":"e_1_3_3_18_2","doi-asserted-by":"publisher","DOI":"10.1136\/bcr-2022-250489"},{"key":"e_1_3_3_19_2","doi-asserted-by":"crossref","unstructured":"Gaillard F Hacking C Silverstone L et al. Hepatic abscess Radiopaedia.org https:\/\/doi.org\/10.53347\/rID-1942 (2008 accessed 23 November 2025).","DOI":"10.53347\/rID-1942"},{"key":"e_1_3_3_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijscr.2025.111971"}],"container-title":["Sage Open Medical Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/2050313X251409861","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/2050313X251409861","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/2050313X251409861","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,1,25]],"date-time":"2026-01-25T20:37:18Z","timestamp":1769373438000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/2050313X251409861"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1]]},"references-count":19,"alternative-id":["10.1177\/2050313X251409861"],"URL":"https:\/\/doi.org\/10.1177\/2050313x251409861","relation":{},"ISSN":["2050-313X","2050-313X"],"issn-type":[{"value":"2050-313X","type":"print"},{"value":"2050-313X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,1]]},"article-number":"2050313X251409861"}}