{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T20:37:02Z","timestamp":1792442222652,"version":"4.5.0"},"reference-count":17,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Sage Open Medical Case Reports"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:p>We present a case of severe and atypical Drug Reaction with Eosinophilia and Systemic Symptoms\/Drug-induced hypersensitivity Symptoms (DRESS\/DiHS), also known as DiHS, in a 46-year-old Chinese woman, triggered by bortezomib (Velcade), a proteasome inhibitor, commonly used for the treatment of multiple myeloma. Bortezomib-induced DRESS\/DiHS syndrome is rare, with this being the second case documented in the literature. The patient presented with severe erythroderma with ichthyosis-like features, hypereosinophilia, and liver injury. Initial response to high dose of solumedrol was followed by relapses upon switching to oral prednisone. Ultimately, the patient responded to dupilumab and maintained complete remission.<\/jats:p>","DOI":"10.1177\/2050313x251411500","type":"journal-article","created":{"date-parts":[[2026,1,25]],"date-time":"2026-01-25T09:58:58Z","timestamp":1769335138000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":2,"title":["Atypical presentation of DRESS\/DiHS mimicking an acquired ichthyosis: A case report of bortezomib-induced severe erythroderma in multiple myeloma"],"prefix":"10.1177","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0009-0009-3931-4801","authenticated-orcid":false,"given":"Cathy","family":"Lu","sequence":"first","affiliation":[{"name":"Faculty of medicine, Universit\u00e9 de Montr\u00e9al, QC, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0974-333X","authenticated-orcid":false,"given":"Lina","family":"Belmesk","sequence":"additional","affiliation":[{"name":"Division of Dermatology, Department of Medicine, Universit\u00e9 de Montr\u00e9al, QC, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-0657-2184","authenticated-orcid":false,"given":"Annie","family":"B\u00e9lisle","sequence":"additional","affiliation":[{"name":"Division of Pathology, Department of Pathology and Cellular Biology, Centre Hospitalier de l'Universit\u00e9 de Montr\u00e9al, QC, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-5397-9543","authenticated-orcid":false,"given":"Marie-Soleil","family":"Masse","sequence":"additional","affiliation":[{"name":"Division of Allergy and Immunology, Department of Medicine, Centre Hospitalier de l'Universit\u00e9 de Montr\u00e9al, QC, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3157-5179","authenticated-orcid":false,"given":"S\u00e9vrine","family":"Ouellette","sequence":"additional","affiliation":[{"name":"Division of Dermatology, Department of Medicine, Universit\u00e9 de Montr\u00e9al, QC, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-5450-6137","authenticated-orcid":false,"given":"Benoit","family":"Cote","sequence":"additional","affiliation":[{"name":"Division of Dermatology, Department of Medicine, Universit\u00e9 de Montr\u00e9al, QC, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2026,1,25]]},"reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.2147\/tcrm.2006.2.3.271"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.3747\/co.21.1798"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.3390\/biomedicines10050999"},{"issue":"6","key":"e_1_3_2_5_2","first-page":"31","article-title":"Drug reaction with eosinophilia and systemic symptoms (DRESS) syndrome","volume":"6","author":"Choudhary S","year":"2013","unstructured":"Choudhary S, McLeod M, Torchia D, et al. Drug reaction with eosinophilia and systemic symptoms (DRESS) syndrome. J Clin Aesthet Dermatol 2013; 6(6): 31\u201337.","journal-title":"J Clin Aesthet Dermatol"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1001\/jamadermatol.2022.4519"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaip.2022.02.004"},{"issue":"12","key":"e_1_3_2_8_2","article-title":"Recurrent drug-induced hypersensitivity syndrome following Bortezomib for multiple Myeloma","volume":"13","author":"Ambur AB","year":"2021","unstructured":"Ambur AB, Nathoo R. Recurrent drug-induced hypersensitivity syndrome following Bortezomib for multiple Myeloma. 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