{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T23:18:25Z","timestamp":1790983105706,"version":"4.1.0"},"reference-count":13,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Sage Open Medical Case Reports"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:p>Pure red cell aplasia is a rare hematologic disorder characterized by severe normocytic anemia, reticulocytopenia, and absence of erythroid precursors. Since the COVID-19 pandemic, pure red cell aplasia has emerged as an uncommon post-infectious complication, likely driven by immune dysregulation. A 72-year-old man developed transfusion-dependent anemia several weeks after a mild COVID-19 infection. Laboratory evaluation revealed normocytic anemia (hemoglobin of 7.0\u2009g\/dL) with profound reticulocytopenia, and bone marrow biopsy showed markedly reduced erythropoiesis with preserved granulopoiesis and megakaryopoiesis. Secondary causes, including nutritional deficiencies, hemolysis, autoimmune disease, parvovirus B19, and hematologic malignancy, were excluded. The patient failed to respond to intravenous immunoglobulin, corticosteroids, and cyclosporine, achieving only a transient partial remission. Rituximab therapy was subsequently initiated and resulted in complete hematologic recovery and sustained remission at 1\u2009year. COVID-19\u2013associated pure red cell aplasia is a rare but clinically important complication. Clinicians should consider it in patients with severe post-COVID anemia, and rituximab may be effective in cases refractory to standard immunosuppressive therapy.<\/jats:p>","DOI":"10.1177\/2050313x251412704","type":"journal-article","created":{"date-parts":[[2026,8,7]],"date-time":"2026-08-07T11:15:08Z","timestamp":1786101308000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":1,"title":["Post\u2013COVID-19 pure red cell aplasia: A case report and literature review"],"prefix":"10.1177","volume":"14","author":[{"given":"Alanoud","family":"Al Shmarri","sequence":"first","affiliation":[{"name":"Internal Medicine, Hamad Medical Corporation (HMC), Doha, Qatar"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-3703-0942","authenticated-orcid":false,"given":"Duha Marwan","family":"Naji","sequence":"additional","affiliation":[{"name":"Internal Medicine, Hamad Medical Corporation (HMC), Doha, Qatar"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elmustafa","family":"Abdalla","sequence":"additional","affiliation":[{"name":"Internal Medicine, Hamad Medical Corporation (HMC), Doha, Qatar"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1393-5302","authenticated-orcid":false,"given":"Abdulrahman F.","family":"Al-Mashdali","sequence":"additional","affiliation":[{"name":"Hematology, National Centre for Cancer Care and Research (NCCCR), Doha, Qatar"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammed","family":"Ahmed","sequence":"additional","affiliation":[{"name":"Internal Medicine, Hamad Medical Corporation (HMC), Doha, Qatar"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"V-Ayah","family":"Elhadi","sequence":"additional","affiliation":[{"name":"Internal Medicine, Hamad Medical Corporation (HMC), Doha, Qatar"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Deena","family":"Mudawi","sequence":"additional","affiliation":[{"name":"Hematology, National Centre for Cancer Care and Research (NCCCR), Doha, Qatar"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0622-8455","authenticated-orcid":false,"given":"Mohammad","family":"Abdulgayoom","sequence":"additional","affiliation":[{"name":"Hematology, National Centre for Cancer Care and Research (NCCCR), Doha, Qatar"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Imran","family":"Ahmad","sequence":"additional","affiliation":[{"name":"Hematopathology, Hamad Medical Corporation (HMC), Doha, Qatar"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samah","family":"Kohla","sequence":"additional","affiliation":[{"name":"Hematopathology, Hamad Medical Corporation (HMC), Doha, Qatar"},{"name":"Weil Cornell Medicine\u2013Qatar, Doha, Qatar"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5066-0125","authenticated-orcid":false,"given":"Sarah","family":"Elkourashy","sequence":"additional","affiliation":[{"name":"Hematology, National Centre for Cancer Care and Research (NCCCR), Doha, Qatar"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shehab F.","family":"Mohamed","sequence":"additional","affiliation":[{"name":"Hematology, National Centre for Cancer Care and Research (NCCCR), Doha, Qatar"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2026,8,7]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2016-05-717140"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.2017.175810"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood.2021010898"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jiac.2021.10.018"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1186\/s13256-022-03545-x"},{"issue":"6","key":"e_1_3_3_7_2","first-page":"1","article-title":"Tacrolimus treatment of pure red cell aplasia due to anti-erythropoietin antibodies induced by COVID-19 in a hemodialysis patient: a case report","volume":"14","author":"Xu L.","year":"2024","unstructured":"Xu L. Tacrolimus treatment of pure red cell aplasia due to anti-erythropoietin antibodies induced by COVID-19 in a hemodialysis patient: a case report. Ann Clin Med Case Rep 2024; 14(6): 1\u20135.","journal-title":"Ann Clin Med Case Rep"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1177\/2040620720940144"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.4103\/ijn.IJN_129_19"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jiac.2023.04.002"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1182\/bloodadvances.2022007174"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.3390\/idr14030044"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2141.2002.3317_3.x"},{"issue":"2","key":"e_1_3_3_14_2","article-title":"Pure red cell aplasia associated with COVID-19 infection: case report","volume":"3","author":"Rangsipat N","year":"2024","unstructured":"Rangsipat N, Elder Z, Heydari H, et al. Pure red cell aplasia associated with COVID-19 infection: case report. Ann Intern Med Clin Cases 2024; 3(2): e230169.","journal-title":"Ann Intern Med Clin Cases"}],"container-title":["Sage Open Medical Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/2050313X251412704","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/2050313X251412704","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/2050313X251412704","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,9]],"date-time":"2026-08-09T14:46:26Z","timestamp":1786286786000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/2050313X251412704"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1]]},"references-count":13,"alternative-id":["10.1177\/2050313X251412704"],"URL":"https:\/\/doi.org\/10.1177\/2050313x251412704","relation":{},"ISSN":["2050-313X","2050-313X"],"issn-type":[{"value":"2050-313X","type":"print"},{"value":"2050-313X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,1]]},"article-number":"2050313X251412704"}}