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It is characterized by acral skin lesions and is commonly associated with autoimmunity and type I interferon pathway activation. Diagnosis is based on clinical features and histological findings. While topical and systemic therapies can be effective, the disease is often chronic and relapsing. We describe a case of a 48-year-old woman with chilblain lupus erythematosus who achieved almost complete clinical remission following treatment with hydroxychloroquine and methotrexate.<\/jats:p>","DOI":"10.1177\/2050313x261415591","type":"journal-article","created":{"date-parts":[[2026,1,30]],"date-time":"2026-01-30T09:32:41Z","timestamp":1769765561000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Chilblain lupus: A rare form of cutaneous lupus erythematosus \u2014 A case report"],"prefix":"10.1177","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0009-0001-6600-1335","authenticated-orcid":false,"given":"Gabriele","family":"Perazzolli","sequence":"first","affiliation":[{"name":"Section of Dermatology and Venereology, Department of Medicine, University of Verona, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-4376-8867","authenticated-orcid":false,"given":"Elia","family":"Banchetti","sequence":"additional","affiliation":[{"name":"Section of Dermatology and Venereology, Department of Medicine, University of Verona, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-9790-7636","authenticated-orcid":false,"given":"Enrico","family":"Melis","sequence":"additional","affiliation":[{"name":"Section of Dermatology and Venereology, Department of Medicine, University of Verona, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Antonio","family":"Carletto","sequence":"additional","affiliation":[{"name":"Section of Rheumatology, Department of Medicine, University of Verona, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giampiero","family":"Girolomoni","sequence":"additional","affiliation":[{"name":"Section of Dermatology and Venereology, Department of Medicine, University of Verona, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1777-9001","authenticated-orcid":false,"given":"Paolo","family":"Gisondi","sequence":"additional","affiliation":[{"name":"Section of Dermatology and Venereology, Department of Medicine, University of Verona, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2026,1,30]]},"reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.31138\/mjr.34.2.269"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1159\/000247494"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.1978.tb01935.x"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1159\/000488543"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/keac231"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1067\/mjd.2001.117861"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2016-209841"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1086\/507848"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11926-017-0689-x"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1159\/000222430"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1001\/jamadermatol.2014.3438"},{"key":"e_1_3_2_13_2","article-title":"LP-204 chilblain lupus erythematosus\u2014a rare encounter","volume":"10","author":"Ali MSM","year":"2023","unstructured":"Ali MSM. LP-204 chilblain lupus erythematosus\u2014a rare encounter. 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