{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,15]],"date-time":"2026-02-15T11:08:17Z","timestamp":1771153697000,"version":"3.50.1"},"reference-count":13,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Sage Open Medical Case Reports"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:p>Denervation pseudohypertrophy is an important and well described, albeit rare, cause of limb swelling that is seldom encountered in the clinical setting. Careful history taking, reasonable clinical suspicion, and referral for magnetic resonance imaging are crucial to arriving at the diagnosis and recommending appropriate treatment. Although typically a slow, insidious process, we report a rare case of acute denervation pseudohypertrophy in a 76-year-old male with diabetic neuropathy, chronic venous insufficiency, and remote tibial fracture repair. Magnetic resonance imaging findings were significant for bilateral denervation pseudohypertrophy of the left greater than right calf muscles with associated diabetic neuropathy. We postulated that the latter is likely the main underlying etiology, particularly given the magnetic resonance imaging\u2019s bilateral findings. The case highlights the importance of considering denervation pseudohypertrophy in the differential diagnosis of acute limb swelling despite its rarity.<\/jats:p>","DOI":"10.1177\/2050313x261422086","type":"journal-article","created":{"date-parts":[[2026,2,12]],"date-time":"2026-02-12T12:59:16Z","timestamp":1770901156000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["A rare, unusually acute presentation of denervation pseudohypertrophy"],"prefix":"10.1177","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0009-0008-5178-7698","authenticated-orcid":false,"given":"Monica","family":"Botross","sequence":"first","affiliation":[{"name":"Burnett School of Medicine at Texas Christian University, Fort Worth, TX, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amirmohammad","family":"Shafiee","sequence":"additional","affiliation":[{"name":"Burnett School of Medicine at Texas Christian University, Fort Worth, TX, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lisa","family":"Couch","sequence":"additional","affiliation":[{"name":"Texas Tech University Health Sciences Center, Lubbock, TX, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Steven","family":"Schultz","sequence":"additional","affiliation":[{"name":"Radiology Associates of North Texas, Fort Worth, TX, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stuart","family":"Pickell","sequence":"additional","affiliation":[{"name":"Burnett School of Medicine at Texas Christian University, Fort Worth, TX, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2026,2,12]]},"reference":[{"key":"e_1_3_2_2_2","first-page":"216","article-title":"Denervation pseudohypertrophy","volume":"107","author":"Ochi M","year":"1988","unstructured":"Ochi M, Awaya S, Kusunoki M, et al. Denervation pseudohypertrophy. Arch Orthop Trauma Surg 1988; 107: 216\u2013218.","journal-title":"Arch Orthop Trauma Surg"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00256-007-0409-0"},{"key":"e_1_3_2_4_2","first-page":"1","article-title":"Pseudohypertrophy of calf muscles: comprehensive guide and insights \u2013 a case report","volume":"6","author":"Labiha A","year":"2020","unstructured":"Labiha A, Patil P, Chitnis A. Pseudohypertrophy of calf muscles: comprehensive guide and insights \u2013 a case report. Int J Med Sci Curr Res 2020; 6: 1\u20134.","journal-title":"Int J Med Sci Curr Res"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.radcr.2022.02.066"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.18214\/jend.2020.22.1.68"},{"key":"e_1_3_2_7_2","first-page":"1447","article-title":"Denervation pseudohypertrophy","volume":"51","author":"Haskell EW","year":"1988","unstructured":"Haskell EW, Denton RL. Denervation pseudohypertrophy. J Neurol Neurosurg Psychiatry 1988; 51: 1447\u20131448.","journal-title":"J Neurol Neurosurg Psychiatry"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.3390\/ijms25031847"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1186\/s40842-024-00194-5"},{"key":"e_1_3_2_10_2","first-page":"1031","article-title":"Diabetic distal pseudohypertrophy","volume":"17","author":"Wilbourn AJ.","year":"1967","unstructured":"Wilbourn AJ. Diabetic distal pseudohypertrophy. Neurology 1967; 17: 1031\u20131038.","journal-title":"Neurology"},{"key":"e_1_3_2_11_2","first-page":"381","article-title":"Muscle atrophy, pseudohypertrophy, and pseudoatrophy","volume":"30","author":"Tsao BE","year":"2010","unstructured":"Tsao BE, Wilbourn AJ. Muscle atrophy, pseudohypertrophy, and pseudoatrophy. 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