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Coexisting conditions like diabetes and hypothyroidism further exacerbate this risk. We report a 34-year-old G2P1 woman at 32\u2009weeks of gestation with type 2 diabetes and treated hypothyroidism who presented with acute pancreatitis and a serum triglyceride level of 33.8\u2009mmol\/L. Her management included therapeutic plasmapheresis, insulin infusion, and fenofibrate, followed by a planned elective caesarean section at 35\u2009weeks, which resulted in the delivery of a healthy infant. This case highlights the critical need for vigilant lipid monitoring and a coordinated, multidisciplinary approach in high-risk pregnancies to prevent life-threatening complications and improve maternal and fetal outcomes.<\/jats:p>","DOI":"10.1177\/2050313x261424320","type":"journal-article","created":{"date-parts":[[2026,5,12]],"date-time":"2026-05-12T09:50:28Z","timestamp":1778579428000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Severe hypertriglyceridemia during pregnancy in a hypothyroid patient: A case report and literature review"],"prefix":"10.1177","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9330-5740","authenticated-orcid":false,"given":"Elabbass A.","family":"Abdelmahmuod","sequence":"first","affiliation":[{"name":"Endocrine Division, Department of Internal Medicine, Hamad Medical Corporation, Doha, Qatar"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-9929-7064","authenticated-orcid":false,"given":"Maab F.","family":"Elhaj","sequence":"additional","affiliation":[{"name":"Endocrine Division, Department of Internal Medicine, Hamad Medical Corporation, Doha, Qatar"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shahd I.","family":"Ibrahim","sequence":"additional","affiliation":[{"name":"Endocrine Division, Department of Internal Medicine, Hamad Medical Corporation, Doha, Qatar"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Salma","family":"Bashir","sequence":"additional","affiliation":[{"name":"Endocrine Division, Department of Internal Medicine, Hamad Medical Corporation, Doha, Qatar"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elhadi","family":"Elouzi","sequence":"additional","affiliation":[{"name":"Endocrine Division, Department of Internal Medicine, Hamad Medical Corporation, Doha, Qatar"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2026,5,12]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1002\/jca.20192"},{"key":"e_1_3_3_3_2","unstructured":"Drugs.com. 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Minerva Ginecol 1996; 48(12): 573\u2013576.","journal-title":"Minerva Ginecol"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.5551\/jat.RV17054"},{"key":"e_1_3_3_8_2","first-page":"59","article-title":"Maternal lipid metabolism and placental lipid transfer","volume":"65","author":"Herrera E","year":"2006","unstructured":"Herrera E, Amusquivar E, L\u00f3pez-Soldado I, et al. Maternal lipid metabolism and placental lipid transfer. Horm Res 2006; 65(Suppl 3): 59\u201364.","journal-title":"Horm Res"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9378(88)90193-7"},{"issue":"6","key":"e_1_3_3_10_2","first-page":"297","article-title":"Lipoprotein metabolism in pregnancy, fat transport to the fetus, and the effects of diabetes","volume":"50","author":"Knopp RH","year":"1986","unstructured":"Knopp RH, Warth MR, Charles D, et al. Lipoprotein metabolism in pregnancy, fat transport to the fetus, and the effects of diabetes. Biol Neonate 1986; 50(6): 297\u2013317.","journal-title":"Biol Neonate"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.5507\/bp.2018.044"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.2174\/1566524023666230605142119"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.atherosclerosis.2021.09.010"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.1111\/tog.12887"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.diabres.2022.109820"},{"key":"e_1_3_3_16_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00404-023-06967-0"},{"issue":"8","key":"e_1_3_3_17_2","article-title":"Complications of hypertriglyceridemia in pregnancy and its impact on neonates: a hospital-based study from Odisha","volume":"14","author":"Dash S","year":"2022","unstructured":"Dash S, Tiwari M, Dash P, et al. Complications of hypertriglyceridemia in pregnancy and its impact on neonates: a hospital-based study from Odisha. 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