{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,6]],"date-time":"2026-04-06T05:08:09Z","timestamp":1775452089648,"version":"3.50.1"},"reference-count":17,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Sage Open Medical Case Reports"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:p>\n                    Fabry disease is a rare X-linked lysosomal storage disorder caused by\n                    <jats:italic toggle=\"yes\">GLA<\/jats:italic>\n                    variants leading to \u03b1-galactosidase A deficiency. The heterozygous phenotype predominantly affects the heart. We report a heterozygous woman in her 70s with known Fabry disease presenting with chest pain and palpitations despite well-controlled cardiovascular risk factors. High-sensitivity troponin remained persistently elevated. Coronary angiography showed non-obstructive arteries, and echocardiography revealed left ventricular hypertrophy without outflow tract obstruction. In the absence of epicardial disease, troponin elevation was attributed to coronary microvascular dysfunction, underscoring its role as a key mechanism of ischaemic symptoms and ongoing myocardial injury in Fabry disease.\n                  <\/jats:p>","DOI":"10.1177\/2050313x261438242","type":"journal-article","created":{"date-parts":[[2026,4,4]],"date-time":"2026-04-04T05:16:10Z","timestamp":1775279770000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Persistent troponin elevation in the heart of Fabry disease due to coronary microvascular dysfunction"],"prefix":"10.1177","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0009-0000-1464-4315","authenticated-orcid":false,"given":"Clement","family":"Tan","sequence":"first","affiliation":[{"name":"Department of Cardiology, Coronary Care Unit &amp; Cardiac Catheterisation Laboratory, Mackay Base Hospital, QLD, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mark Daniel","family":"Higgins","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Coronary Care Unit &amp; Cardiac Catheterisation Laboratory, Mackay Base Hospital, QLD, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhihua","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Coronary Care Unit &amp; Cardiac Catheterisation Laboratory, Mackay Base Hospital, QLD, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matthew","family":"Hiskens","sequence":"additional","affiliation":[{"name":"Mackay Institute of Research and Innovation, Mackay Base Hospital, QLD, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2026,4,3]]},"reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2020.12.024"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.108.841494"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.3390\/ijms22094434"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinbiochem.2023.03.004"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.31083\/j.rcm2306201"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cca.2020.02.013"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.2217\/fca-2016-0012"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jclinepi.2017.04.026"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcard.2017.08.068"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.acvd.2019.01.002"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.15420\/ecr.2019.28.2"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0091757"},{"key":"e_1_3_2_14_2","volume-title":"Fabry disease. (FL)","author":"Bokhari SRA","year":"2024","unstructured":"Bokhari SRA, Zulfiqar H, Hariz A. Fabry disease. (FL), S.I.T.I., Ed.; StatPearls Publishing, 2024."},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.3949\/ccjm.88a.20140"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehae666.2331"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2261-11-6"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcard.2017.09.027"}],"container-title":["Sage Open Medical Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/2050313X261438242","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/2050313X261438242","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/2050313X261438242","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,6]],"date-time":"2026-04-06T03:46:26Z","timestamp":1775447186000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/2050313X261438242"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1]]},"references-count":17,"alternative-id":["10.1177\/2050313X261438242"],"URL":"https:\/\/doi.org\/10.1177\/2050313x261438242","relation":{},"ISSN":["2050-313X","2050-313X"],"issn-type":[{"value":"2050-313X","type":"print"},{"value":"2050-313X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,1]]},"article-number":"2050313X261438242"}}