{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,22]],"date-time":"2026-04-22T13:31:29Z","timestamp":1776864689222,"version":"3.51.2"},"reference-count":14,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"name":"Tarsus Pharmaceuticals, Inc."}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Sage Open Medical Case Reports"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:p>\n                    <jats:italic toggle=\"yes\">Demodex<\/jats:italic>\n                    blepharitis is a chronic inflammatory ocular condition caused by\n                    <jats:italic toggle=\"yes\">Demodex<\/jats:italic>\n                    mite infestation of the eyelid that can negatively impact quality of life. Currently, lotilaner ophthalmic solution 0.25% is the only FDA-approved treatment for\n                    <jats:italic toggle=\"yes\">Demodex<\/jats:italic>\n                    blepharitis. The\n                    <jats:italic toggle=\"yes\">Demodex<\/jats:italic>\n                    Expert Panel on Treatment and Eyelid Health has established consensus that lotilaner ophthalmic solution 0.25% should be considered the preferred first-line treatment for\n                    <jats:italic toggle=\"yes\">Demodex<\/jats:italic>\n                    blepharitis. We report a patient who presented with collarettes, the pathognomonic sign of\n                    <jats:italic toggle=\"yes\">Demodex<\/jats:italic>\n                    blepharitis, meibomian gland dysfunction, and poor visual acuity. The patient also had a history of neovascular age-related macular degeneration. Consistent with the\n                    <jats:italic toggle=\"yes\">Demodex<\/jats:italic>\n                    Expert Panel on Treatment and Eyelid Health consensus recommendations, the patient was treated with lotilaner ophthalmic solution 0.25%, lid scrubs, and warm compresses. At the 2-month follow-up, collarettes had resolved, and signs of meibomian gland dysfunction had improved. This case supports the\n                    <jats:italic toggle=\"yes\">Demodex<\/jats:italic>\n                    Expert Panel on Treatment and Eyelid Health recommendation that lotilaner ophthalmic solution 0.25% should be considered the preferred first-line treatment for\n                    <jats:italic toggle=\"yes\">Demodex<\/jats:italic>\n                    blepharitis.\n                  <\/jats:p>","DOI":"10.1177\/2050313x261443128","type":"journal-article","created":{"date-parts":[[2026,4,20]],"date-time":"2026-04-20T13:04:14Z","timestamp":1776690254000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Lotilaner ophthalmic solution 0.25% in the treatment of\n                    <i>Demodex<\/i>\n                    blepharitis: A case report"],"prefix":"10.1177","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1390-2532","authenticated-orcid":false,"given":"Paul","family":"Karpecki","sequence":"first","affiliation":[{"name":"Kentucky Eye Institute, Lexington, KY, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Brandon","family":"Ayres","sequence":"additional","affiliation":[{"name":"Wills Eye Hospital, Philadelphia, PA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5235-1780","authenticated-orcid":false,"given":"Eric","family":"Donnenfeld","sequence":"additional","affiliation":[{"name":"Ophthalmic Consultants of Long Island, NY, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marjan","family":"Farid","sequence":"additional","affiliation":[{"name":"Gavin Herbert Eye Institute, UC-Irvine, CA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7472-8457","authenticated-orcid":false,"given":"Ian Benjamin","family":"Gaddie","sequence":"additional","affiliation":[{"name":"Gaddie Eye Centers, Louisville, KY, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0895-7870","authenticated-orcid":false,"given":"Preeya K.","family":"Gupta","sequence":"additional","affiliation":[{"name":"Triangle Eye Consultants, Raleigh, NC, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6718-7418","authenticated-orcid":false,"given":"Cecelia","family":"Koetting","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, University of Colorado School of Medicine, Aurora, CO, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Richard","family":"Lindstrom","sequence":"additional","affiliation":[{"name":"Minnesota Eye Consultants, Bloomington, MN, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1892-2428","authenticated-orcid":false,"given":"Selina","family":"McGee","sequence":"additional","affiliation":[{"name":"BeSpoke Vision, Edmond, OK, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2937-1457","authenticated-orcid":false,"given":"Kelly K.","family":"Nichols","sequence":"additional","affiliation":[{"name":"School of Optometry, University of Alabama at Birmingham, AL, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9036-5158","authenticated-orcid":false,"given":"Laura M.","family":"Periman","sequence":"additional","affiliation":[{"name":"Periman Eye Institute, Seattle, WA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9341-3482","authenticated-orcid":false,"given":"Stephen","family":"Pflugfelder","sequence":"additional","affiliation":[{"name":"Baylor College of Medicine, Houston, TX, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9882-7249","authenticated-orcid":false,"given":"Christopher","family":"Starr","sequence":"additional","affiliation":[{"name":"Weill Cornell Medicine, New York, NY, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nandini","family":"Venkateswaran","sequence":"additional","affiliation":[{"name":"Massachusetts Eye and Ear, Harvard Medical School, Boston, MA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3453-3062","authenticated-orcid":false,"given":"Elizabeth","family":"Yeu","sequence":"additional","affiliation":[{"name":"Virginia Eye Consultants, Norfolk, VA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2026,4,20]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41433-023-02500-4"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.2147\/OPTH.S374530"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.2147\/OPTH.S399989"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12886-024-03765-3"},{"key":"e_1_3_3_6_2","unstructured":"XDEMVY. Highlights of prescribing information https:\/\/tarsusrx.com\/wp-content\/uploads\/XDEMVY-Prescribing-Information-24JUL23.pdf (2023 accessed 27 July 2025)."},{"key":"e_1_3_3_7_2","unstructured":"Tarsus News Release. FDA approves XDEMVY\u2122 (lotilaner ophthalmic solution) 0.25% for the treatment of Demodex blepharitis (press release) http:\/\/ir.tarsusrx.com\/news-releases\/news-release-details\/fda-approves-xdemvytm-lotilaner-ophthalmic-solution-025 (2023 accessed 31 July 2025)."},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1155\/2021\/3862684"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1089\/jop.2021.0011"},{"key":"e_1_3_3_10_2","article-title":"Safety and efficacy of lotilaner ophthalmic solution 0.25% for the treatment of Demodex blepharitis: the EUROPA Study","volume":"62","author":"Gonzalez-Salinas R","year":"2021","unstructured":"Gonzalez-Salinas R, Yeu E, Quiroz-Mercado H, et al. Safety and efficacy of lotilaner ophthalmic solution 0.25% for the treatment of Demodex blepharitis: the EUROPA Study. Invest Ophthalmol Vis Sci 2021; 62: 1332.","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.clae.2021.101492"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1097\/ICO.0000000000003097"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2023.05.030"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.2147\/OPTH.S525681"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.1097\/ICL.0000000000001003"}],"container-title":["Sage Open Medical Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/2050313X261443128","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/2050313X261443128","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/2050313X261443128","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,22]],"date-time":"2026-04-22T12:16:16Z","timestamp":1776860176000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/2050313X261443128"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1]]},"references-count":14,"alternative-id":["10.1177\/2050313X261443128"],"URL":"https:\/\/doi.org\/10.1177\/2050313x261443128","relation":{},"ISSN":["2050-313X","2050-313X"],"issn-type":[{"value":"2050-313X","type":"print"},{"value":"2050-313X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,1]]},"article-number":"2050313X261443128"}}