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This report describes a 38-year-old man who presented with gastrointestinal symptoms and was found to have a giant sessile polyp in the colon. Routine preoperative evaluation revealed elevated serum insulin-like growth factor-1 and unsuppressed growth hormone levels, leading to the diagnosis of acromegaly, which was confirmed by a pituitary MRI that showed a macroadenoma. This case highlights that unusually large colonic polyps in younger patients should prompt consideration of systemic etiologies, including endocrine disorders. A multidisciplinary approach, integrating gastroenterological and endocrinological assessment, is essential for early diagnosis and management to reduce morbidity.<\/jats:p>","DOI":"10.1177\/2050313x261444508","type":"journal-article","created":{"date-parts":[[2026,5,16]],"date-time":"2026-05-16T13:08:54Z","timestamp":1778936934000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["More than just a polyp: Hidden acromegaly behind a giant colonic mass"],"prefix":"10.1177","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9330-5740","authenticated-orcid":false,"given":"Elabbass A.","family":"Abdelmahmuod","sequence":"first","affiliation":[{"name":"Endocrine Section, Department of Medicine, Hamad Medical Corporation, Doha, Qatar"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tarik","family":"Elhadd","sequence":"additional","affiliation":[{"name":"Endocrine Section, Department of Medicine, Hamad Medical Corporation, Doha, Qatar"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2026,5,16]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI39375"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.2147\/IJGM.S38594"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ecl.2020.05.007"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11102-016-0725-2"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2265.2009.03626.x"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1210\/er.2002-0022"},{"issue":"18","key":"e_1_3_3_8_2","first-page":"1731","article-title":"Acromegaly","volume":"382","author":"Melmed S.","year":"2020","unstructured":"Melmed S. 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