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We report and discuss a case of refractory childhood granulomatous periorificial dermatitis in a 14-year-old female with past inhaled corticosteroid use. After 7\u2009months of isotretinoin therapy followed by 3\u2009months of oral methotrexate, we observed complete resolution of her facial eruption.<\/jats:p>","DOI":"10.1177\/2050313x261446086","type":"journal-article","created":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T09:42:36Z","timestamp":1777542156000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Treatment-resistant granulomatous periorificial dermatitis in a 14-year-old female: Resolution after oral isotretinoin and methotrexate \u2013 A case report"],"prefix":"10.1177","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4416-5520","authenticated-orcid":false,"given":"Manu","family":"Jagdeo","sequence":"first","affiliation":[{"name":"Department of Medicine, Rady Faculty of Health Sciences, University of Manitoba, Winnipeg, MB, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1963-8197","authenticated-orcid":false,"given":"Jill","family":"Keddy-Grant","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Winnipeg Clinic, MB, Canada"},{"name":"Department of Pediatrics and Child Health, Rady Faculty of Health Sciences, University of Manitoba, Winnipeg, MB, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2026,4,30]]},"reference":[{"key":"e_1_3_3_2_2","unstructured":"Gianotti F Ermacora E Bennelli MG et al. 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