{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,9]],"date-time":"2026-05-09T10:10:54Z","timestamp":1778321454667,"version":"3.51.4"},"reference-count":15,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"name":"the CAMS Innovation Fund for Medical Science","award":["2023-I2M-C&T-B-085"],"award-info":[{"award-number":["2023-I2M-C&T-B-085"]}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Sage Open Medical Case Reports"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:p>Gardner syndrome, a subtype of familial adenomatous polyposis, features colorectal polyposis, osteomas and soft-tissue tumors with elevated colorectal carcinoma risk, and abdominal masses in these patients are easily misdiagnosed as malignant recurrence, especially with concomitant bone lesions. We report a 33-year-old female familial adenomatous polyposis patient with a history of surgically treated stage IIIA colorectal adenocarcinoma, who presented with a 3-month abdominal mass. Contrast-enhanced computed tomography indicated a large cystic-solid mass with lymphadenopathy and peritoneal thickening, suggesting recurrence, while magnetic resonance imaging suggested a desmoid tumor and identified bilateral femoral head avascular necrosis. Surgical resection and pathogenic adenomatous polyposis coli gene mutation detection confirmed an abdominal desmoid tumor. This case highlights that Gardner syndrome can induce benign space-occupying desmoid tumors, and for familial adenomatous polyposis patients with bone lesions, combining advanced imaging, histopathology and genetic testing is critical to avoid misdiagnosis and unnecessary interventions for suspected cancer recurrence.<\/jats:p>","DOI":"10.1177\/2050313x261448324","type":"journal-article","created":{"date-parts":[[2026,5,6]],"date-time":"2026-05-06T03:59:01Z","timestamp":1778039941000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Desmoid tumor mimicking cancer recurrence in a patient with colon cancer and Gardner syndrome: A case report"],"prefix":"10.1177","volume":"14","author":[{"given":"Jing","family":"Zhang","sequence":"first","affiliation":[{"name":"Medical School, Southeast University, Nanjing, Jiangsu, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yan","family":"Fu","sequence":"additional","affiliation":[{"name":"Department of Interventional Therapy, National Cancer Center, National Clinical Research Center for Cancer, Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1606-7528","authenticated-orcid":false,"given":"Peng","family":"Zeng","sequence":"additional","affiliation":[{"name":"Department of Oncology, Zhongda Hospital, Medical School, Southeast University, Nanjing, Jiangsu, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2026,5,5]]},"reference":[{"key":"e_1_3_2_2_2","first-page":"242","article-title":"Gardner\u2019s syndrome\u2014the importance of early diagnosis: a case report and a review","volume":"56","author":"Buch B","year":"2001","unstructured":"Buch B, Noffke C, de Kock S. Gardner\u2019s syndrome\u2014the importance of early diagnosis: a case report and a review. SADJ 2001; 56: 242\u2013245.","journal-title":"SADJ"},{"key":"e_1_3_2_3_2","first-page":"853","article-title":"A tale of four syndromes: familial adenomatous polyposis, Gardner syndrome, attenuated APC and Turcot syndrome","volume":"88","author":"Foulkes WD.","year":"1995","unstructured":"Foulkes WD. A tale of four syndromes: familial adenomatous polyposis, Gardner syndrome, attenuated APC and Turcot syndrome. QJM 1995; 88: 853\u2013863.","journal-title":"QJM"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(09)70167-6"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.2165\/11311180-000000000-00000"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-7697(08)70288-6"},{"key":"e_1_3_2_7_2","first-page":"1355","article-title":"[Desmoid tumors in patients with familial adenomatous polyposis]","volume":"146","author":"Pikaar A","year":"2002","unstructured":"Pikaar A, Nortier JWR, Griffioen G, et al. [Desmoid tumors in patients with familial adenomatous polyposis]. Ned Tijdschr Geneeskd 2002; 146: 1355\u20131359.","journal-title":"Ned Tijdschr Geneeskd"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.3389\/pore.2024.1611768"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1148\/rg.271065065"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.pas.0000213348.65014.0a"},{"key":"e_1_3_2_11_2","first-page":"329","article-title":"Increased beta-catenin protein and somatic APC mutations in sporadic aggressive fibromatoses (desmoid tumors)","volume":"151","author":"Alman BA","year":"1997","unstructured":"Alman BA, Li C, Pajerski ME, et al. Increased beta-catenin protein and somatic APC mutations in sporadic aggressive fibromatoses (desmoid tumors). Am J Pathol 1997; 151: 329\u2013334.","journal-title":"Am J Pathol"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1097\/CCO.0000000000000854"},{"key":"e_1_3_2_13_2","first-page":"327","article-title":"The diagnosis and surgical treatment of patients with Gardner\u2019s syndrome","volume":"82","author":"Watne AL","year":"1977","unstructured":"Watne AL, Lai HY, Carrier J, et al. The diagnosis and surgical treatment of patients with Gardner\u2019s syndrome. Surgery 1977; 82: 327\u2013333.","journal-title":"Surgery"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1259\/dmfr.21.2.1327886"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF02554079"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1245\/s10434-012-2638-2"}],"container-title":["Sage Open Medical Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/2050313X261448324","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/2050313X261448324","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/2050313X261448324","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,9]],"date-time":"2026-05-09T09:52:52Z","timestamp":1778320372000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/2050313X261448324"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1]]},"references-count":15,"alternative-id":["10.1177\/2050313X261448324"],"URL":"https:\/\/doi.org\/10.1177\/2050313x261448324","relation":{},"ISSN":["2050-313X","2050-313X"],"issn-type":[{"value":"2050-313X","type":"print"},{"value":"2050-313X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,1]]},"article-number":"2050313X261448324"}}