{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,30]],"date-time":"2026-08-30T11:33:53Z","timestamp":1788089633687,"version":"build-2803163510"},"reference-count":12,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Sage Open Medical Case Reports"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:p>Lichen planus is a chronic immune-mediated inflammatory disorder, and vulvar lichen planus (VLP) is a debilitating subtype often refractory to standard therapy. Emerging evidence on Janus kinase\u2013signal transducer and activator of transcription pathway dysregulation in the pathogenesis of VLP supports Janus kinase inhibition as a potential therapeutic strategy. We report a 71-year-old woman with chronic VLP, including severe pruritus, pain, erosive erythema, and progressive vulvar scarring, who failed multiple topical and systemic therapies. These therapies included topical and oral corticosteroids, mycophenolate mofetil, acitretin, tacrolimus, and roflumilast, which were discontinued due to inadequate response or intolerance. Following the initiation of topical ruxolitinib 1.5% cream twice daily, she achieved complete resolution of erythema, pruritus, and burning after 3\u2009months, without local or systemic adverse effects. This is the first reported case of VLP treated with a topical Janus kinase inhibitor, supporting topical Janus kinase inhibition as a steroid-sparing therapeutic option for refractory disease; however, cost and access may limit its use.<\/jats:p>","DOI":"10.1177\/2050313x261463898","type":"journal-article","created":{"date-parts":[[2026,7,11]],"date-time":"2026-07-11T06:04:51Z","timestamp":1783749891000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":1,"title":["Erosive vulvar lichen planus improved with topical ruxolitinib: A case report"],"prefix":"10.1177","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8427-0849","authenticated-orcid":false,"given":"Rahila","family":"Shaikh","sequence":"first","affiliation":[{"name":"Faculty of Medicine, University of Ottawa, ON, Canada"},{"name":"Division of Dermatology, The Ottawa Hospital, ON, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5967-2539","authenticated-orcid":false,"given":"Carly","family":"Kirshen","sequence":"additional","affiliation":[{"name":"Division of Dermatology, The Ottawa Hospital, ON, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2026,7,10]]},"reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1601-0825.2005.01142.x"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.142.3.289"},{"key":"e_1_3_2_4_2","volume-title":"Genital dermatology atlas","author":"Edwards L","year":"2010","unstructured":"Edwards L, Lynch PJ. Genital dermatology atlas. 2nd ed. Lippincott Williams & Wilkins, 2010.","edition":"2"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1396-0296.2004.04005.x"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1155\/2014\/742826"},{"issue":"8","key":"e_1_3_2_7_2","first-page":"1023","article-title":"Oral lichen planus treated with the JAK inhibitor tofacitinib","volume":"155","author":"Liu V","year":"2019","unstructured":"Liu V, Mackool BT. Oral lichen planus treated with the JAK inhibitor tofacitinib. JAMA Dermatol 2019; 155(8): 1023\u20131024.","journal-title":"JAMA Dermatol"},{"issue":"6","key":"e_1_3_2_8_2","first-page":"1295","article-title":"Janus kinase inhibitors for lichen planus: a systematic review and meta-analysis","volume":"35","author":"Phan K","year":"2021","unstructured":"Phan K, Charlton O, Smith SD. Janus kinase inhibitors for lichen planus: a systematic review and meta-analysis. J Eur Acad Dermatol Venereol 2021; 35(6): 1295\u20131303.","journal-title":"J Eur Acad Dermatol Venereol"},{"issue":"4","key":"e_1_3_2_9_2","first-page":"1098","article-title":"Treatment of inflammatory skin diseases with JAK inhibitors","volume":"142","author":"Kim BS","year":"2018","unstructured":"Kim BS, Howell MD, Sun K, et al. Treatment of inflammatory skin diseases with JAK inhibitors. J Allergy Clin Immunol 2018; 142(4): 1098\u20131106.","journal-title":"J Allergy Clin Immunol"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2133.1996.d01-939.x"},{"issue":"1","key":"e_1_3_2_11_2","first-page":"20","article-title":"The management of oral and vulval lichen planus: a consensus statement","volume":"176","author":"Setterfield JF","year":"2017","unstructured":"Setterfield JF, Neill S, Shirlaw PJ, et al. The management of oral and vulval lichen planus: a consensus statement. Br J Dermatol 2017; 176(1): 20\u201326.","journal-title":"Br J Dermatol"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.134.12.1521"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-4632.2009.04062.x"}],"container-title":["Sage Open Medical Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/2050313X261463898","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/2050313X261463898","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/2050313X261463898","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,13]],"date-time":"2026-07-13T07:18:19Z","timestamp":1783927099000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/2050313X261463898"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1]]},"references-count":12,"alternative-id":["10.1177\/2050313X261463898"],"URL":"https:\/\/doi.org\/10.1177\/2050313x261463898","relation":{},"ISSN":["2050-313X","2050-313X"],"issn-type":[{"value":"2050-313X","type":"print"},{"value":"2050-313X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,1]]},"article-number":"2050313X261463898"}}