{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,19]],"date-time":"2026-09-19T13:06:40Z","timestamp":1789823200256,"version":"4.0.1"},"reference-count":9,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Sage Open Medical Case Reports"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:p>Calcinosis cutis is an uncommon but clinically significant complication of dermatomyositis, occurring in approximately 11%\u201320% of adult patients. We report a case of rapidly progressive, extensive calcinosis cutis in a 52-year-old woman with adult-onset dermatomyositis. Despite ongoing systemic immunosuppressive therapy, she developed biopsy-confirmed calcinosis within 3\u2009months of initial presentation, with subsequent extension to the bilateral axillae, anterior chest wall, and proximal thighs causing functional impairment. Myositis-specific antibody panel results are pending. This case illustrates the aggressive potential of calcinosis in adult dermatomyositis, the limited therapeutic options once calcification is established, and the importance of early aggressive disease control.<\/jats:p>","DOI":"10.1177\/2050313x261463982","type":"journal-article","created":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T05:12:23Z","timestamp":1789621943000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Rapidly progressive calcinosis cutis in adult-onset dermatomyositis: A case report"],"prefix":"10.1177","volume":"14","author":[{"given":"Elona","family":"Bebla","sequence":"first","affiliation":[{"name":"California Health Sciences University, Clovis, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Attiya","family":"Haroon","sequence":"additional","affiliation":[{"name":"California Health Sciences University, Clovis, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2026,9,16]]},"reference":[{"key":"e_1_3_2_2_2","volume-title":"Dermatomyositis: New insights","author":"Valenzuela A","year":"2020","unstructured":"Valenzuela A, Chung L. Calcinosis in dermatomyositis: current concepts and emerging treatments. In: Ramirez Curtis M (ed.) Dermatomyositis: New insights. IntechOpen, 2020."},{"issue":"3","key":"e_1_3_2_3_2","first-page":"102988","article-title":"Pathogenesis of calcinosis in dermatomyositis: role of mitochondria and interferon signaling","volume":"21","author":"Davuluri S","year":"2022","unstructured":"Davuluri S, Misra DP, Agarwal V. Pathogenesis of calcinosis in dermatomyositis: role of mitochondria and interferon signaling. Autoimmun Rev 2022; 21(3): 102988.","journal-title":"Autoimmun Rev"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1001\/jamadermatol.2013.10416"},{"issue":"12","key":"e_1_3_2_5_2","first-page":"4135","article-title":"Late-onset juvenile dermatomyositis: distinct features of a rare autoimmune condition","volume":"64","author":"Mamyrova G","year":"2012","unstructured":"Mamyrova G, Kleiner DE, James-Newton L, et al. Late-onset juvenile dermatomyositis: distinct features of a rare autoimmune condition. Arthritis Rheum 2012; 64(12): 4135\u20134143.","journal-title":"Arthritis Rheum"},{"issue":"2","key":"e_1_3_2_6_2","first-page":"812","article-title":"Risk factors for calcinosis in adult patients with dermatomyositis","volume":"60","author":"Jiang W","year":"2021","unstructured":"Jiang W, Xu J, Wu M, et al. Risk factors for calcinosis in adult patients with dermatomyositis. Rheumatology (Oxford) 2021; 60(2): 812\u2013819.","journal-title":"Rheumatology (Oxford)"},{"issue":"3","key":"e_1_3_2_7_2","first-page":"534","article-title":"Plain radiography is effective for the detection and characterization of calcinosis cutis","volume":"70","author":"Shahi V","year":"2014","unstructured":"Shahi V, Wetter DA, Howe BM, et al. Plain radiography is effective for the detection and characterization of calcinosis cutis. J Am Acad Dermatol 2014; 70(3): 534\u2013540.","journal-title":"J Am Acad Dermatol"},{"issue":"4","key":"e_1_3_2_8_2","first-page":"492","article-title":"Surgical treatment of calcinosis cutis in the pediatric patient","volume":"141","author":"Saddic N","year":"2005","unstructured":"Saddic N, Miller JJ, Miller OF, et al. Surgical treatment of calcinosis cutis in the pediatric patient. Arch Dermatol 2005; 141(4): 492\u2013497.","journal-title":"Arch Dermatol"},{"issue":"2","key":"e_1_3_2_9_2","first-page":"170","article-title":"Extensive calcinosis cutis in juvenile dermatomyositis","volume":"80","author":"Chander R","year":"2014","unstructured":"Chander R, Makkar S, Mendiratta V, et al. Extensive calcinosis cutis in juvenile dermatomyositis. Indian J Dermatol Venereol Leprol 2014; 80(2): 170\u2013173.","journal-title":"Indian J Dermatol Venereol Leprol"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2117912"}],"container-title":["Sage Open Medical Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/2050313X261463982","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/2050313X261463982","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/2050313X261463982","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,19]],"date-time":"2026-09-19T12:18:15Z","timestamp":1789820295000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/2050313X261463982"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1]]},"references-count":9,"alternative-id":["10.1177\/2050313X261463982"],"URL":"https:\/\/doi.org\/10.1177\/2050313x261463982","relation":{},"ISSN":["2050-313X","2050-313X"],"issn-type":[{"value":"2050-313X","type":"print"},{"value":"2050-313X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,1]]},"article-number":"2050313X261463982"}}