{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,16]],"date-time":"2026-07-16T07:06:56Z","timestamp":1784185616696,"version":"3.55.0"},"reference-count":15,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Sage Open Medical Case Reports"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:p>\n                    This is a care of endophthalmitis following XEN45 Gel Stent implantation managed with combined corneal transplant and pars plana vitrectomy, and to review reported cases of endophthalmitis after minimally invasive glaucoma surgery. A 67-year-old male with primary open-angle glaucoma developed endophthalmitis 2\u2009months after XEN45 implantation. Upon referral to our tertiary care center, he underwent urgent implant removal, penetrating keratoplasty with temporary keratoprosthesis, and pars plana vitrectomy with intravitreal antibiotics. Cultures grew\n                    <jats:italic toggle=\"yes\">Streptococcus gordonii<\/jats:italic>\n                    . A second corneal transplant with fresh donor tissue was performed 4\u2009months later. Despite vision limited to light perception, the infection resolved and the eye was preserved. This is the first reported case of XEN45 Gel Stent-associated endophthalmitis which was successfully controlled with combined keratoplasty and vitrectomy. Our review of published cases identified 45 minimally invasive glaucoma surgery-related endophthalmitis cases, with XEN45 accounting for 58%. Potential risk factors included the XEN45 stent\u2019s susceptibility to exposure after conjunctival erosion, pool water exposure, and ab externo insertion during implantation. In cases of XEN45 Gel Stent-associated endophthalmitis, corneal transplant with pars plana vitrectomy could be a successful strategy to control infection and spare the globe.\n                  <\/jats:p>","DOI":"10.1177\/2050313x261465147","type":"journal-article","created":{"date-parts":[[2026,7,13]],"date-time":"2026-07-13T09:00:41Z","timestamp":1783933241000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Endophthalmitis in XEN45 Gel Stent: Case report and review of the literature"],"prefix":"10.1177","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6230-2536","authenticated-orcid":false,"given":"William","family":"Xu","sequence":"first","affiliation":[{"name":"Department of Ophthalmology, University of Florida, Gainesville, FL, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anjay","family":"Shah","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, University of Florida, Gainesville, FL, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kristin","family":"Ates Hicks","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, University of Florida, Gainesville, FL, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0292-3661","authenticated-orcid":false,"given":"Lauren","family":"Jeang","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, University of Florida, Gainesville, FL, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4092-7009","authenticated-orcid":false,"given":"Jinghua","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, University of Florida, Gainesville, FL, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2026,7,13]]},"reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"crossref","unstructured":"Lewis RA. Ab interno approach to the subconjunctival space using a collagen glaucoma stent. J Cataract Refract Surg 2014; 40(8): 1301\u20131306. https:\/\/doi.org\/10.1016\/j.jcrs.2014.01.032","DOI":"10.1016\/j.jcrs.2014.01.032"},{"key":"e_1_3_2_3_2","doi-asserted-by":"crossref","unstructured":"Jampel HD Solus JF Tracey PA et al. Outcomes and bleb-related complications of trabeculectomy. Ophthalmology 2012; 119(4): 712\u2013722. https:\/\/doi.org\/10.1016\/j.ophtha.2011.09.049","DOI":"10.1016\/j.ophtha.2011.09.049"},{"key":"e_1_3_2_4_2","doi-asserted-by":"crossref","unstructured":"Starr MR Huang D Israilevich RN et al. Endophthalmitis after minimally invasive glaucoma surgery. Ophthalmology 2021; 128(12): 1777\u20131779. https:\/\/doi.org\/10.1016\/j.ophtha.2021.06.004","DOI":"10.1016\/j.ophtha.2021.06.004"},{"key":"e_1_3_2_5_2","doi-asserted-by":"crossref","unstructured":"Burggraaf-S\u00e1nchez de Las Matas R Such-Irusta L Alfonso-Mu\u00f1oz EA et al. Late-onset endophthalmitis after XEN45\u00ae implantation: a retrospective case series and literature review. J Curr Glaucoma Pract 2021; 15(3): 153\u2013160. https:\/\/doi.org\/10.5005\/jp-journals-10078-1316","DOI":"10.5005\/jp-journals-10078-1316"},{"key":"e_1_3_2_6_2","doi-asserted-by":"crossref","unstructured":"Sabharwal J Dai X Dun C et al. Early endophthalmitis incidence and risk factors after glaucoma surgery in the Medicare population from 2016 to 2019. Ophthalmology 2024; 131(2): 179\u2013187. https:\/\/doi.org\/10.1016\/j.ophtha.2023.09.008","DOI":"10.1016\/j.ophtha.2023.09.008"},{"key":"e_1_3_2_7_2","doi-asserted-by":"crossref","unstructured":"Al-Torbak AA Al-Shahwan S Al-Jadaan I et al. Endophthalmitis associated with the Ahmed glaucoma valve implant. 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