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While research on Human Papilloma Virus has traditionally focused on its role in cervical cancer pathogenesis, such infection is also highly prevalent in the male population. Despite this, the clinical management of Human Papilloma Virus in men still remains limited, with no universally accepted screening protocols or therapeutic guidelines. This clinical case series describes six male patients (aged 26\u201366\u2009years) with Human Papilloma Virus infection detected in samples of urethral mucosa, anal mucosa, or seminal fluid. Each patient took the dietary supplement containing epigallocatechin gallate (200\u2009mg), folic acid (400\u2009\u03bcg), vitamin B12 (1\u2009mg), and hyaluronic acid (50\u2009mg) daily for up to 6\u2009months. After the oral supplementation, each patient reported complete Human Papilloma Virus clearance. These findings provide, for the first time, preliminary evidence on the positive effect of such molecules in promoting Human Papilloma Virus clearance across different male anatomical sites, including anal and urethral mucosa and seminal fluid. Although preliminary, this report highlights the often-overlooked issue of Human Papilloma Virus management in men, thus paving the way for additional clinical studies with the aim of defining the role of such dietary supplements in counteracting Human Papilloma Virus infection in men.<\/jats:p>","DOI":"10.1177\/2050313x261477889","type":"journal-article","created":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T03:16:02Z","timestamp":1786590962000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Epigallocatechin gallate, folic acid, vitamin B12 and hyaluronic acid in the management of male Human Papilloma Virus Infection: A case series"],"prefix":"10.1177","volume":"14","author":[{"given":"Valdemaro Gianmaria","family":"Pavacci","sequence":"first","affiliation":[{"name":"Department of General and Applied Hygiene, UniCamillus\u2014Saint Camillus International University of Health Sciences, Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ludovica","family":"Di Fraia","sequence":"additional","affiliation":[{"name":"Di Fraia Laboratori s.r.l., Colleferro, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1805-3181","authenticated-orcid":false,"given":"Vittorio","family":"Unfer","sequence":"additional","affiliation":[{"name":"A.G.Un.Co. Obstetrics and Gynaecology Center, Rome, Italy"},{"name":"Department of Gynecology and Obstetrics, UniCamillus\u2014Saint Camillus International University of Health Sciences, Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2026,8,12]]},"reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"crossref","unstructured":"Kombe AJ Li B Zahid A et al. Epidemiology and burden of human papillomavirus and related diseases molecular pathogenesis and vaccine evaluation. Front Public Health 2020; 8: 552028. https:\/\/doi.org\/10.3389\/fpubh.2020.552028","DOI":"10.3389\/fpubh.2020.552028"},{"key":"e_1_3_2_3_2","doi-asserted-by":"crossref","unstructured":"Patra S Shand H Ghosal S et al. HPV and male cancer: pathogenesis prevention and impact. 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