{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T07:12:08Z","timestamp":1788505928772,"version":"build-2803163510"},"reference-count":22,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Sage Open Medical Case Reports"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:p>Cellular neurothekeoma is a benign cutaneous soft tissue neoplasm that usually arises in the upper parts of the body and affects mainly young individuals with a female predominance. This type of tumor shows a spectrum of atypical or \u201cunusual\u201d pathologic features that challenge pathologists in making a correct diagnosis. Herein, we present a case of cellular neurothekeoma with prominent myxoid features and dense interstitial chronic inflammatory cell infiltrate arising in a 28-year-old female as a nodule in the left popliteal fossa. Following a thorough literature search, this case is considered to be the first report of a cellular neurothekeoma arising in the popliteal fossa. The data presented in this case expand our knowledge of the diverse anatomical distributions and wide pathologic spectrum of cellular neurothekeomas.<\/jats:p>","DOI":"10.1177\/2050313x261483464","type":"journal-article","created":{"date-parts":[[2026,8,31]],"date-time":"2026-08-31T10:03:30Z","timestamp":1788170610000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["A case of cellular myxoid neurothekeoma with unusual clinicopathologic features"],"prefix":"10.1177","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8131-1438","authenticated-orcid":false,"given":"Rana S.","family":"AL-Zaidi","sequence":"first","affiliation":[{"name":"Anatomic Pathology Section, Department of Laboratory and Blood Bank, King Faisal Hospital, Makkah, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2026,8,31]]},"reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"crossref","unstructured":"Gallager RL Helwig EB. Neurothekeoma\u2014a benign cutaneous tumor of neural origin. Am J Clin Pathol 1980; 74(6): 759\u2013764. https:\/\/doi.org\/10.1093\/ajcp\/74.6.759","DOI":"10.1093\/ajcp\/74.6.759"},{"key":"e_1_3_2_3_2","doi-asserted-by":"crossref","unstructured":"Stratton J Billings SD. Cellular neurothekeoma: analysis of 37 cases emphasizing atypical histologic features. Mod Pathol 2014; 27(5): 701\u2013710. https:\/\/doi.org\/10.1038\/modpathol.2013.190","DOI":"10.1038\/modpathol.2013.190"},{"key":"e_1_3_2_4_2","doi-asserted-by":"crossref","unstructured":"Fetsch JF Laskin WB Hallman JR et al. Neurothekeoma: an analysis of 178 tumors with detailed immunohistochemical data and long-term patient follow-up information. Am J Surg Pathol 2007; 31(7): 1103\u20131114. https:\/\/doi.org\/10.1097\/PAS.0b013e31802d96af","DOI":"10.1097\/PAS.0b013e31802d96af"},{"key":"e_1_3_2_5_2","doi-asserted-by":"crossref","unstructured":"Hornick JL Fletcher CD. Cellular neurothekeoma: detailed characterization in a series of 133 cases. Am J Surg Pathol 2007; 31(3): 329\u2013340. https:\/\/doi.org\/10.1097\/01.pas.0000213360.03133.89","DOI":"10.1097\/01.pas.0000213360.03133.89"},{"key":"e_1_3_2_6_2","doi-asserted-by":"crossref","unstructured":"Busam KJ Mentzel T Colpaert C et al. Atypical or worrisome features in cellular neurothekeoma: a study of 10 cases. Am J Surg Pathol 1998; 22(9): 1067\u20131072. https:\/\/doi.org\/10.1097\/00000478-199809000-00004","DOI":"10.1097\/00000478-199809000-00004"},{"key":"e_1_3_2_7_2","doi-asserted-by":"crossref","unstructured":"Gagnier JJ Kienle G Altman DG et al. The CARE guidelines: consensus-based clinical case reporting guideline development. Glob Adv Health Med 2013; 2(5): 38\u201343. https:\/\/doi.org\/10.7453\/gahmj.2013.008","DOI":"10.7453\/gahmj.2013.008"},{"key":"e_1_3_2_8_2","unstructured":"Brenn T Lazar AJ Requena L et al. Benign neoplasms of uncertain differentiation. 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Atypical cellular neurothekeoma: a case report with a novel NF1 mutation. Diagn Pathol 2024; 19(1): 151. https:\/\/doi.org\/10.1186\/s13000-024-01578-y","DOI":"10.1186\/s13000-024-01578-y"},{"key":"e_1_3_2_12_2","doi-asserted-by":"crossref","unstructured":"Fullen DR Lowe L Su LD. Antibody to S100a6 protein is a sensitive immunohistochemical marker for neurothekeoma. J Cutan Pathol 2003; 30(2): 118\u2013122. https:\/\/doi.org\/10.1034\/j.1600-0560.2002.00032.x","DOI":"10.1034\/j.1600-0560.2002.00032.x"},{"key":"e_1_3_2_13_2","doi-asserted-by":"crossref","unstructured":"Wang AR May D Bourne P et al. PGP9.5: a marker for cellular neurothekeoma. Am J Surg Pathol 1999; 23(11): 1401\u20131407. https:\/\/doi.org\/10.1097\/00000478-199911000-00011","DOI":"10.1097\/00000478-199911000-00011"},{"key":"e_1_3_2_14_2","doi-asserted-by":"crossref","unstructured":"Wang GY Nazarian RM Zhao L et al. Protein gene product 9.5 (PGP9.5) expression in benign cutaneous mesenchymal histiocytic and melanocytic lesions: comparison with cellular neurothekeoma. Pathology 2017; 49(1): 44\u201349. https:\/\/doi.org\/10.1016\/j.pathol.2016.09.061","DOI":"10.1016\/j.pathol.2016.09.061"},{"key":"e_1_3_2_15_2","doi-asserted-by":"crossref","unstructured":"Sheth S Li X Binder S et al. Differential gene expression profiles of neurothekeomas and nerve sheath myxomas by microarray analysis. Mod Pathol 2011; 24(3): 343\u2013354. https:\/\/doi.org\/10.1038\/modpathol.2010.203","DOI":"10.1038\/modpathol.2010.203"},{"key":"e_1_3_2_16_2","doi-asserted-by":"crossref","unstructured":"Fox MD Billings SD Gleason BC et al. Expression of MiTF may be helpful in differentiating cellular neurothekeoma from plexiform fibrohistiocytic tumor (histiocytoid predominant) in a partial biopsy specimen. 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Cellular neurothekeoma is driven by copy number deletions providing potential diagnostic and therapeutic avenues. Br J Dermatol 2026; 194(3): 593\u2013595. https:\/\/doi.org\/10.1093\/bjd\/ljaf487","DOI":"10.1093\/bjd\/ljaf487"},{"key":"e_1_3_2_23_2","doi-asserted-by":"crossref","unstructured":"Ortega M Sparks J Nava VE et al. Neurothekeoma with PI3K w552* ALK P1469S SMO G461S and ERBB3 L77M genetic alterations. 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