{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,6]],"date-time":"2026-09-06T04:12:35Z","timestamp":1788667955156,"version":"build-2803163510"},"reference-count":15,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Sage Open Medical Case Reports"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:p>Gastric carcinomas with squamous differentiation are exceptionally rare and diagnostically difficult, particularly on limited biopsy material. We report a case of an HIV-positive man in his mid-60s who presented with abdominal pain, melena, and unintentional weight loss. Initial upper endoscopy revealed a large, ulcerated mass involving the gastric fundus and cardia; superficial endoscopic biopsies were non-diagnostic. Endoscopic ultrasound\u2013guided biopsy demonstrated invasive squamous cell carcinoma without a glandular component, and the tumor was staged cT4b cN1 cM0 (clinical Stage IVA, AJCC\/UICC eighth edition). The biopsy interpretation was treated as provisional, since sampling of this extent cannot exclude a glandular component. After neoadjuvant FLOT chemotherapy, total gastrectomy with multivisceral resection yielded gastric adenosquamous carcinoma with hepatic metastatic adenocarcinoma, establishing M1 disease and Stage IV. A pure squamous phenotype in a gastric biopsy is therefore not sufficient to diagnose primary gastric squamous cell carcinoma; the distinction rests on the resection specimen. The patient\u2019s HIV infection is relevant background rather than a demonstrated cause.<\/jats:p>","DOI":"10.1177\/2050313x261486169","type":"journal-article","created":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T22:03:23Z","timestamp":1788386603000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Gastric adenosquamous carcinoma with an apparently pure squamous phenotype on limited biopsy in a patient with HIV: A case report"],"prefix":"10.1177","volume":"14","author":[{"given":"Mohamed A.","family":"Youssef","sequence":"first","affiliation":[{"name":"University of Texas Medical Branch"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zahra Sarrafan","family":"Chaharsoughi","sequence":"additional","affiliation":[{"name":"University of Texas Medical Branch"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1752-6845","authenticated-orcid":false,"given":"Celeste E.","family":"Wagner","sequence":"additional","affiliation":[{"name":"University of Texas Medical Branch"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hafiz","family":"Ghani","sequence":"additional","affiliation":[{"name":"University of Texas Medical Branch"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sreeram","family":"Parupudi","sequence":"additional","affiliation":[{"name":"University of Texas Medical Branch"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ranjana","family":"Nawgiri","sequence":"additional","affiliation":[{"name":"University of Texas Medical Branch"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2026,9,2]]},"reference":[{"key":"e_1_3_6_2_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(196911)24:5<985::AID-CNCR2820240518>3.0.CO;2-4"},{"issue":"2","key":"e_1_3_6_3_2","first-page":"e54188","article-title":"Primary Squamous Cell Carcinoma of the Stomach: A Case Report","volume":"16","author":"Fernandes YR","year":"2024","unstructured":"Fernandes YR, Morais KB, Campos AC, et al. Primary Squamous Cell Carcinoma of the Stomach: A Case Report. Cureus 2024; 16(2): e54188. https:\/\/doi.org\/10.7759\/cureus.54188","journal-title":"Cureus"},{"key":"e_1_3_6_4_2","doi-asserted-by":"publisher","DOI":"10.3892\/mco.2023.2677"},{"key":"e_1_3_6_5_2","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-319-40618-3"},{"issue":"4","key":"e_1_3_6_6_2","first-page":"376","article-title":"Oncologic outcomes of patients with resectable primary gastric squamous cell carcinoma: a systematic review","volume":"35","author":"Schizas D","year":"2022","unstructured":"Schizas D, Papaconstantinou D, Syllaios A, et al. Oncologic outcomes of patients with resectable primary gastric squamous cell carcinoma: a systematic review. 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