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All received esomeprazole 20\u2009mg b.d. for 7\u00a0days, followed by 40\u2009mg o.d. to complete an 8\u2010week course, and were followed up for 32 weeks by telephone.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In this study, 198\/589 (34%) patients were<jats:italic>H. pylori<\/jats:italic>\u2010positive and 113<jats:italic>H. pylori<\/jats:italic>\u2010negative patients served as controls. Baseline endoscopy revealed 63% Los Angeles grade 0A and 37% Los Angeles grade BCD oesophagitis with no difference between patient groups. Symptom improvement on esomeprazole was seen in 89%.<jats:italic>H. pylori<\/jats:italic>eradication was successful in 82%.<jats:italic>H. pylori<\/jats:italic>eradication had no effect on symptomatic relapse (hazard ratio 1.15, 95% CI 0.74\u20131.8;<jats:italic>p<\/jats:italic>\u2009=\u20090.5). Overall,<jats:italic>H. pylori<\/jats:italic>\u2010positive patients had a lower probability of relapse compared to<jats:italic>H. pylori<\/jats:italic>\u2010negative controls (hazard ratio 0.6, 95% CI 0.43\u20130.85;<jats:italic>p<\/jats:italic>\u2009=\u20090.004). Relapse hazard was modulated also by oesophagitis grade (BCD vs. 0A, hazard ratio 2.1, 95% CI 1.5\u20133.0).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Relapse of gastro\u2010oesophageal reflux disease symptoms after a course of high dose acid suppression took longer for<jats:italic>H. pylori<\/jats:italic>\u2010positive patients than<jats:italic>H. pylori<\/jats:italic>\u2010negative controls; however eradication therapy had no effect on the risk of relapse; ClincialTrials.gov number, NCT00574925.<\/jats:p><\/jats:sec>","DOI":"10.1177\/2050640613484020","type":"journal-article","created":{"date-parts":[[2013,3,29]],"date-time":"2013-03-29T03:34:23Z","timestamp":1364528063000},"page":"226-235","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":16,"title":["The effect of<i>Helicobacter pylori<\/i>infection and eradication in patients with gastro\u2010oesophageal reflux disease: A 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