{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,29]],"date-time":"2026-05-29T14:04:07Z","timestamp":1780063447289,"version":"3.54.0"},"reference-count":16,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2013,8,1]],"date-time":"2013-08-01T00:00:00Z","timestamp":1375315200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2013,8,1]],"date-time":"2013-08-01T00:00:00Z","timestamp":1375315200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["UEG Journal"],"published-print":{"date-parts":[[2013,8]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Detection of early oesophageal cancer in surrounding normal tissue can be challenging, but detection is essential to determine the subsequent treatment. Dysplastic tissue can be detected by using electrical impedance spectroscopy (EIS).<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>The aim of the present study was to evaluate the feasibility and value of EIS in the diagnosis of oesophageal neoplasia.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This prospective ex\u2010vivo study included 23 patients with early oesophageal cancer (17 with Barrett\u2019s cancer and six with early squamous cell cancer). Immediately after endoscopic resection, the electrical properties of the resected specimens were investigated using a pencil probe (5\u2009mm in diameter, frequency range from 100\u00a0Hz to 1\u2009MHz). Punch biopsies were taken from the measured site in order to compare the results of EIS with histology.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>EIS was able to detect dysplastic oesophageal mucosa with a high rate of accuracy (82% in Barrett\u2019s oesophagus and 100% in squamous oesophagus) A total of 54 different sites in 26 tumours were evaluated.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>EIS was able to differentiate reliably between non\u2010neoplastic and neoplastic oesophageal mucosa. Using EIS, it might be possible to use it for targeted biopsies and to avoid unnecessary biopsies during cancer surveillance in future.<\/jats:p><\/jats:sec>","DOI":"10.1177\/2050640613495198","type":"journal-article","created":{"date-parts":[[2013,6,25]],"date-time":"2013-06-25T02:42:11Z","timestamp":1372128131000},"page":"236-241","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":10,"title":["Diagnosing early Barrett\u2019s neoplasia and oesophageal squamous cell neoplasia by bioimpedance spectroscopy in human tissue"],"prefix":"10.1002","volume":"1","author":[{"given":"Mate","family":"Knabe","sequence":"first","affiliation":[{"name":"HSK Wiesbaden (Teaching Hospital of the University of Mainz) Wiesbaden Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian","family":"Kurz","sequence":"additional","affiliation":[{"name":"Fraunhofer Institute for Biomedical Engineering IBMT St. Ingbert 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