{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T13:57:19Z","timestamp":1790517439581,"version":"4.1.0"},"reference-count":41,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2013,10,1]],"date-time":"2013-10-01T00:00:00Z","timestamp":1380585600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2013,10,1]],"date-time":"2013-10-01T00:00:00Z","timestamp":1380585600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["UEG Journal"],"published-print":{"date-parts":[[2013,10]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>Functional gastrointestinal disorders (FGID) have been shown to be associated with both comorbid mood disorders and traumatic events such as abuse earlier in life. In a longitudinal study, we tested a model that hypothesized: (i) childhood abuse was associated with subsequent mood disorder and pain or interference in life by bowel symptoms both directly and indirectly via neurotic personality; and (ii) an ongoing cycle of mood disorder impacts on bowel symptoms.<\/jats:p><\/jats:sec><jats:sec><jats:title>Design<\/jats:title><jats:p>Subjects from the general population classified as irritable bowel syndrome and\/or functional dyspepsia (IBS\/FD, <jats:italic>n<\/jats:italic> \u2009=\u2009207) or free of FGID (<jats:italic>n<\/jats:italic> \u2009=\u2009100) were prospectively studied every 6\u00a0months over 18\u00a0months. In addition to bowel symptom interference and abdominal pain, measures of personality (neuroticism), childhood abuse history, depression, and anxiety were obtained. The hypothesized model was tested via Path Modelling.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Childhood abuse was found to be directly associated with neuroticism but only indirectly associated with baseline interference and mood disorders (via neuroticism). The data further supported an ongoing cycle of elevations in mood disorders and pain\/interference by bowel symptoms. The data supported direct effects of interference at one time point on interference at the subsequent time point in addition to indirect effects of prior anxiety and depression. Repeating the model with pain frequency as the outcome yielded almost identical findings which suggests the findings are generalized across domains of symptoms and quality\u2010of\u2010life.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Our data provide support for a model characterized by a \u2018vicious circle\u2019 between mood disorders and FGID symptoms in adulthood, with initial input from early life factors.<\/jats:p><\/jats:sec>","DOI":"10.1177\/2050640613498383","type":"journal-article","created":{"date-parts":[[2013,7,18]],"date-time":"2013-07-18T03:19:49Z","timestamp":1374117589000},"page":"394-402","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":44,"title":["Early life factors initiate a \u2018vicious circle\u2019 of affective and gastrointestinal symptoms: A longitudinal study"],"prefix":"10.1002","volume":"1","author":[{"given":"Michael P","family":"Jones","sequence":"first","affiliation":[{"name":"Macquarie University North Ryde NSW Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lukas","family":"Van Oudenhove","sequence":"additional","affiliation":[{"name":"University of Leuven Leuven Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Natasha","family":"Koloski","sequence":"additional","affiliation":[{"name":"University of Newcastle Callaghan NSW Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jan","family":"Tack","sequence":"additional","affiliation":[{"name":"University of Leuven Leuven Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicholas J","family":"Talley","sequence":"additional","affiliation":[{"name":"University of Newcastle Callaghan NSW Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2013,10]]},"reference":[{"key":"e_1_2_8_2_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.2002.05783.x"},{"key":"e_1_2_8_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0149-2918(02)85143-8"},{"key":"e_1_2_8_4_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.2000.01735.x"},{"key":"e_1_2_8_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2010.03.003"},{"key":"e_1_2_8_6_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2036.2003.t01-1-01736.x"},{"key":"e_1_2_8_7_2","doi-asserted-by":"publisher","DOI":"10.2165\/00019053-200624010-00002"},{"key":"e_1_2_8_8_2","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-113-11-828"},{"key":"e_1_2_8_9_2","volume-title":"The functional gastrointestinal disorders. 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