{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T09:25:23Z","timestamp":1782984323781,"version":"3.54.5"},"reference-count":19,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2013,10,1]],"date-time":"2013-10-01T00:00:00Z","timestamp":1380585600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2013,10,1]],"date-time":"2013-10-01T00:00:00Z","timestamp":1380585600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["UEG Journal"],"published-print":{"date-parts":[[2013,10]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>Epidemiological and clinical information on fibrolamellar hepatocellular carcinoma (fHCC) is scarce. We performed a Surveillance, Epidemiology and End Results (SEER) database analysis with the aim of collecting information to better understand the biology and clinical aspects of this rare disease.<\/jats:p><\/jats:sec><jats:sec><jats:title>Design<\/jats:title><jats:p>Incidence trends, race\u2010 and age\u2010specific rates, tumor size, first course surgery and five\u2010year relative survival of 191 US cases (SEER) diagnosed with fHCC during 2000\u20132010 were compared to cases with hepatocellular carcinoma (HCC), HCC\u2010not otherwise specified (HCC\u2010NOS) and other HCC\u2010types.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>While HCC\u2010NOS incidence rates increased by 5.2% annually from 2000\u20132008 (<jats:italic>p<\/jats:italic> \u2009&lt;\u20090.05) before leveling, the 1.3% change in fHCC incidence was not statistically significant. The rates of fHCC were similar across ethnic groups while HCC\u2010NOS incidence rates were higher among non\u2010whites. Although 16% of fHCC patients had primary tumors \u22645\u2009cm compared to 37% of HCC\u2010NOS cases five\u2010year survival was better among fHCC (34%) than HCC\u2010NOS cases (16%). Fibrolamellar HCC cases of 0\u201339 years of age were more likely to receive radiofrequency ablation, transplant or resection than HCC\u2010NOS cases of that age. Survival was similar among fibrolamellar and HCC\u2010NOS cases receiving surgery.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>In this largest case series, fibrolamellar and HCC\u2010NOS age\u2010 and race\u2010specific incidence rates and time trends differed. Despite larger tumor size than HCC\u2010NOS cases fibrolamellar cases received surgery more often and had better survival rates. Differences in co\u2010morbidity may influence treatment. Studies of fHCC biology, including by age, are recommended.<\/jats:p><\/jats:sec>","DOI":"10.1177\/2050640613501507","type":"journal-article","created":{"date-parts":[[2013,8,17]],"date-time":"2013-08-17T01:52:41Z","timestamp":1376704361000},"page":"351-357","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":109,"title":["Fibrolamellar hepatocellular carcinoma in the USA, 2000\u20132010: A detailed report on frequency, treatment and outcome based on the Surveillance, Epidemiology, and End Results database"],"prefix":"10.1002","volume":"1","author":[{"given":"Tobias","family":"Eggert","sequence":"first","affiliation":[{"name":"Gastrointestinal Malignancy Section Medical Oncology Branch National Cancer Institute Bethesda USA"},{"name":"Department of Gastroenterology Hepatology and Endocrinology School of Medicine Hannover Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katherine A","family":"McGlynn","sequence":"additional","affiliation":[{"name":"Division of Cancer Epidemiology and Genetics National Cancer Institute Rockville USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Austin","family":"Duffy","sequence":"additional","affiliation":[{"name":"Gastrointestinal Malignancy Section Medical Oncology Branch National Cancer Institute Bethesda USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael P","family":"Manns","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Hepatology and Endocrinology School of Medicine Hannover Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tim F","family":"Greten","sequence":"additional","affiliation":[{"name":"Gastrointestinal Malignancy Section Medical Oncology Branch National Cancer Institute Bethesda USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sean F","family":"Altekruse","sequence":"additional","affiliation":[{"name":"Division of Cancer Control &amp; Population Sciences National Cancer Institute Rockville USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2013,10]]},"reference":[{"key":"e_1_2_8_2_2","unstructured":"International Agency for Research on Cancer. 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