{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,2]],"date-time":"2026-11-02T19:15:22Z","timestamp":1793646922870,"version":"4.5.1"},"reference-count":23,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2013,12,1]],"date-time":"2013-12-01T00:00:00Z","timestamp":1385856000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2013,12,1]],"date-time":"2013-12-01T00:00:00Z","timestamp":1385856000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"DOI":"10.13039\/100008373","name":"Takeda Pharmaceutical Company","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008373","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["UEG Journal"],"published-print":{"date-parts":[[2013,12]]},"abstract":"<jats:sec><jats:title>Background:<\/jats:title><jats:p>Since the publication of the Rome III criteria for functional dyspepsia (FD), the evidence about the efficacy of half\u2010dose of proton pump inhibitors for dyspepsia symptoms have been limited.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective:<\/jats:title><jats:p>To examine the efficacy of lansoprazole for functional dyspepsia (FD) diagnosed with the Rome III criteria by the multicentre, double\u2010blind, randomized, placebo\u2010controlled study in Japan.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods:<\/jats:title><jats:p>A total of 54 FD participants were randomized to lansoprazole 15\u2009mg once daily or placebo for a 4\u2010week double\u2010blind treatment period. The primary efficacy endpoint was an overall dyspeptic symptom relief rate evaluated by 5\u2010point Likert scale scores. The alteration of dyspeptic symptom scores during the study period was also assessed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results:<\/jats:title><jats:p>At week 4, the overall dyspeptic symptom relief rates were higher in the lansoprazole group (30.4%) than in the placebo group (6.7%) (<jats:italic>p<\/jats:italic> \u2009=\u20090.045). The scores for epigastric pain (<jats:italic>p<\/jats:italic> \u2009=\u20090.045) and epigastric burning (<jats:italic>p<\/jats:italic> \u2009=\u20090.03) were significantly improved in the lansoprazole group compared to the placebo group, whereas the improvement of the scores for postprandial fullness (<jats:italic>p<\/jats:italic> \u2009=\u20090.81) and early satiation (<jats:italic>p<\/jats:italic> \u2009=\u20090.33) was not different between lansoprazole and placebo groups.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions:<\/jats:title><jats:p>Lansoprazole 15\u00a0mg ameliorates dyspeptic symptoms, particularly the epigastric pain syndrome\u2010related symptoms of FD.<\/jats:p><\/jats:sec>","DOI":"10.1177\/2050640613510904","type":"journal-article","created":{"date-parts":[[2013,11,5]],"date-time":"2013-11-05T03:56:28Z","timestamp":1383623788000},"page":"445-452","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":46,"title":["Effect of lansoprazole on the epigastric symptoms of functional dyspepsia (ELF study): A multicentre, prospective, randomized, double\u2010blind, placebo\u2010controlled clinical trial"],"prefix":"10.1002","volume":"1","author":[{"given":"Hidekazu","family":"Suzuki","sequence":"first","affiliation":[{"name":"Division of Gastroenterology and Hepatology Department of Internal Medicine Keio University School of Medicine Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroaki","family":"Kusunoki","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology Department of Internal Medicine Kawasaki Medical University 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