{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T18:38:00Z","timestamp":1790620680948,"version":"4.1.0"},"reference-count":28,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2014,4,1]],"date-time":"2014-04-01T00:00:00Z","timestamp":1396310400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2014,4,1]],"date-time":"2014-04-01T00:00:00Z","timestamp":1396310400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["UEG Journal"],"published-print":{"date-parts":[[2014,4]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Peroral endoscopic myotomy (POEM) has been recently introduced in clinical practice for the treatment of achalasia. The endoluminal functional lumen imaging probe (EndoFLIP) system) uses impedance planimetry for the real\u2010time measurement of the diameter of the oesophago\u2010gastric junction.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>The aim of this study is to prospectively evaluate the effect of POEM on the oesophago\u2010gastric junction using EndoFLIP.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>All the patients who underwent POEM in a single centre between April and July 2013 were enrolled in the study. EndoFLIP was used intraoperatively, immediately before and after POEM. During follow\u2010up patients underwent oesophagogastroduodenoscopy, oesophageal pH monitoring and manometry. Clinical outcomes were compared with the diameter of the oesophago\u2010gastric junction after POEM.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In total, 23 patients (12\u00a0males, mean age 51.7 years) were enrolled, and 21 underwent POEM successfully. Preoperative mean basal lower oesophageal sphincter pressure was 42.1\u2009mmHg (\u00b117.6). Before POEM, the mean oesophago\u2010gastric junction diameter and cross\u2010sectional area were 6.3\u2009mm (\u00b11.8) and 32.9\u00a0mm<jats:sup>2<\/jats:sup> (\u00b123.1), respectively. After treatment, the mean diameter and cross\u2010sectional area of the oesophago\u2010gastric junction were 11.3\u2009mm (\u00b11.7 SD) and 102.38\u00a0mm<jats:sup>2<\/jats:sup> (\u00b128.2 SD), respectively. No complications occurred during a mean follow\u2010up of 5\u00a0months. Median post\u2010operative Eckardt score was 1. Three patients (14.3%) referred heartburn. Follow\u2010up studies revealed gastro\u2010oesophageal reflux disease (GORD) in 57.1% of patients and oesophagitis in 33.3%. No correlations were observed between the diameter of oesophago\u2010gastric junction after POEM and symptoms relief, GORD incidence and lower oesophageal sphincter pressure.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The diameter of oesophago\u2010gastric junction substantially increases after POEM. EndoFLIP is a reliable method for the intraoperative evaluation of oesophago\u2010gastric junction diameter. However, the real usefulness of this technology after POEM remains controversial.<\/jats:p><\/jats:sec>","DOI":"10.1177\/2050640614521193","type":"journal-article","created":{"date-parts":[[2014,1,21]],"date-time":"2014-01-21T02:37:16Z","timestamp":1390271836000},"page":"77-83","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":78,"title":["EndoFLIP system for the intraoperative evaluation of peroral endoscopic myotomy"],"prefix":"10.1002","volume":"2","author":[{"given":"Pietro","family":"Familiari","sequence":"first","affiliation":[{"name":"Digestive Endoscopy Unit Gemelli University Hospital Universit\u00e0 Cattolica del Sacro Cuore Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giovanni","family":"Gigante","sequence":"additional","affiliation":[{"name":"Digestive Endoscopy Unit Gemelli University Hospital Universit\u00e0 Cattolica del Sacro Cuore Rome 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