{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T15:28:06Z","timestamp":1790177286945,"version":"4.1.0"},"reference-count":25,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2014,6,1]],"date-time":"2014-06-01T00:00:00Z","timestamp":1401580800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2014,6,1]],"date-time":"2014-06-01T00:00:00Z","timestamp":1401580800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"DOI":"10.13039\/501100004431","name":"Fondation de France","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004431","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100006364","name":"Institut National Du Cancer","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100006364","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["UEG Journal"],"published-print":{"date-parts":[[2014,6]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>Acute gastrointestinal graft\u2010versus\u2010host disease (GI\u2010GVHD) is usually diagnosed using endoscopic examinations and biopsies for conventional histology. The aim of this pilot study was to determine whether mini\u2010invasive techniques such as probe\u2010based confocal laser endomicroscopy (pCLE) combined with wireless capsule endoscopy (WCE) could detect early lesions of GI\u2010GVHD prior to symptoms.<\/jats:p><\/jats:sec><jats:sec><jats:title>Design<\/jats:title><jats:p>Fifteen patients undergoing allogeneic haematopoietic stem cell transplantation (allo\u2010HSCT) were prospectively examined with a small bowel WCE, duodenal and colorectal pCLE, and standard biopsies. Per study protocol, all these examinations were scheduled between day 21 and day 28 after allo\u2010HSCT, independently of the presence or absence of digestive symptoms.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>During follow up, eight patients developed acute GI\u2010GVHD. Sensitivity of WCE, pCLE, and histology were 50, 87.5, and 50%, respectively. Specificity of WCE, pCLE, and histology were 80, 71.5, and 80%, respectively. We showed a positive correlation between the Gl\u00fccksberg scoring system and WCE (<jats:italic>rho<\/jats:italic> \u2009=\u20090.543, <jats:italic>p<\/jats:italic> \u2009=\u20090.036) and pCLE (<jats:italic>rho<\/jats:italic> \u2009=\u20090.727, <jats:italic>p<\/jats:italic> \u2009=\u20090.002) but not with standard histology (<jats:italic>rho<\/jats:italic> \u2009=\u20090.481, <jats:italic>p<\/jats:italic> \u2009=\u20090.069).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The results from this pilot study suggest that novel methods such as pCLE and WCE could be part of a mini\u2010invasive algorithm for early detection of GI\u2010GVHD.<\/jats:p><\/jats:sec>","DOI":"10.1177\/2050640614529283","type":"journal-article","created":{"date-parts":[[2014,4,4]],"date-time":"2014-04-04T04:20:36Z","timestamp":1396585236000},"page":"206-215","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":18,"title":["Early detection of acute graft\u2010versus\u2010host disease by wireless capsule endoscopy and probe\u2010based confocal laser endomicroscopy: results of a pilot study"],"prefix":"10.1002","volume":"2","author":[{"given":"Emmanuel","family":"Coron","sequence":"first","affiliation":[{"name":"Institut des Maladies de l\u2019Appareil Digestif CHU Universit\u00e9 de Nantes Nantes France"},{"name":"INSERM UMR 913 Universit\u00e9 de Nantes Nantes France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valerie","family":"Laurent","sequence":"additional","affiliation":[{"name":"Institut des Maladies de l\u2019Appareil Digestif CHU 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