{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,28]],"date-time":"2026-08-28T02:47:33Z","timestamp":1787885253489,"version":"build-2784847793"},"reference-count":39,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2015,4,1]],"date-time":"2015-04-01T00:00:00Z","timestamp":1427846400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2015,4,1]],"date-time":"2015-04-01T00:00:00Z","timestamp":1427846400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["UEG Journal"],"published-print":{"date-parts":[[2015,4]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Dental erosion is a complication of gastro\u2010oesophageal reflux disease (GORD) according to the Montreal consensus statement. However, GORD has not been comprehensively characterized in patients with dental erosions and pH\u2010impedance measures have not been reported.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objectives<\/jats:title><jats:p>Characterize GORD in patients with dental erosions using 24\u2010h multichannel intraluminal pH\u2010impedance measurements (pH\u2010MII) and endoscopy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This single\u2010centre study investigated reflux in successive patients presenting to dentists with dental erosion using pH\u2010MII and endoscopy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Of the 374 patients, 298 (80%) reported GORD symptoms &lt;2 per week, 72 (19%) had oesophagitis and 59 (16%) had a hiatal hernia. In the 349 with pH\u2010MII the mean percentage time with a pH &lt;4 (95% CI) was 11.0 (9.3\u201312.7), and 34.4% (31.9\u201336.9) for a pH &lt;5.5, a critical threshold for dental tissue. The mean numbers of total, acidic and weakly acidic reflux episodes were 71 (63\u201379), 43 (38\u201349) and 31 (26\u201335), respectively. Of the reflux episodes, 19% (17\u201321) reached the proximal oesophagus. In 241 (69%) patients reflux was abnormal using published normal values for acid exposure time and reflux episodes. No significant associations between the severity of dental erosions and any reflux variables were found. The presence of GORD symptoms and of oesophagitis or a hiatal hernia was associated with greater reflux, but not with increased dental erosion scores.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Significant oligosymptomatic gastro\u2010oesophageal reflux occurs in the majority of patients with dental erosion. The degree of dental erosion did not correlate with any of the accepted quantitative reflux indicators. Definition of clinically relevant reflux parameters by pH\u2010MII for dental erosion and of treatment guidelines are outstanding. Gastroenterologists and dentists need to be aware of the widely prevalent association between dental erosion and atypical GORD.<\/jats:p><\/jats:sec>","DOI":"10.1177\/2050640614550852","type":"journal-article","created":{"date-parts":[[2014,9,12]],"date-time":"2014-09-12T04:51:13Z","timestamp":1410497473000},"page":"174-181","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":27,"title":["Gastro\u2010oesophageal reflux is common in oligosymptomatic patients with dental erosion: A pH\u2010impedance and endoscopic study"],"prefix":"10.1002","volume":"3","author":[{"given":"Clive H","family":"Wilder-Smith","sequence":"first","affiliation":[{"name":"Brain-Gut Research Group Gastroenterology Group Practice Bern Switzerland"},{"name":"Department of Preventive, Restorative and Pediatric Dentistry University of Bern Bern Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Materna","sequence":"additional","affiliation":[{"name":"Brain-Gut Research Group Gastroenterology Group Practice Bern Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lukas","family":"Martig","sequence":"additional","affiliation":[{"name":"Institute of Mathematical Statistics and Actuarial Science University of Bern Bern Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adrian","family":"Lussi","sequence":"additional","affiliation":[{"name":"Department of Preventive, Restorative and Pediatric Dentistry University of Bern Bern Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,4]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.2006.00630.x"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1590-8658(03)00215-9"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-122-11-199506010-00001"},{"key":"e_1_2_7_5_1","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1016\/0030-4220(94)90168-6","article-title":"Oral and dental manifestations in gastrooesophageal reflux disease","volume":"78","author":"Meurmann J","year":"1994","journal-title":"Oral Surg Oral Med Oral Pathol"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1532-849X.1997.tb00108.x"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2842.1996.tb00855.x"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bdj.4809187"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1741-2358.2002.00005.x"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.0909-8836.1998.eos106302.x"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jdent.2004.03.004"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1159\/000201365"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/0030-4220(88)90113-2"},{"key":"e_1_2_7_14_1","first-page":"210","article-title":"Dental erosions caused by gastroesophageal reflux disease in children","volume":"60","author":"Aine L","year":"1993","journal-title":"ASDC J Dent Child"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1601-0825.1997.tb00053.x"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1080\/00016350310001433"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1834-7819.2002.tb00321.x"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1067\/mpd.2002.123285"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jdent.2013.08.018"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2036.2008.03694.x"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2036.2003.01606.x"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.2006.00936.x"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2036.2005.02677.x"},{"key":"e_1_2_7_24_1","first-page":"351","article-title":"Dental erosion as oral disease. 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