{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,6]],"date-time":"2025-08-06T12:10:21Z","timestamp":1754482221121},"reference-count":33,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2015,10,1]],"date-time":"2015-10-01T00:00:00Z","timestamp":1443657600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2015,10,1]],"date-time":"2015-10-01T00:00:00Z","timestamp":1443657600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["UEG Journal"],"published-print":{"date-parts":[[2015,10]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Gender differences may exist in the symptom experience of patients with gastro\u2010oesophageal reflux disease (GERD) who have a partial response to proton pump inhibitors (PPIs).<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>The purpose of this study was to analyse gender differences in partial responders to PPIs.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Patients with GERD who responded partially to PPIs (<jats:italic>n<\/jats:italic> \u2009=\u2009580; NCT00703534) completed the Reflux Symptom Questionnaire 7\u2010day recall (RESQ\u20107) and the Gastrointestinal Symptom Rating Scale (GSRS). Anxiety and depression were evaluated using the Hospital Anxiety and Depression Scale.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Women had significantly higher RESQ\u20107 domain scores than men for Heartburn (frequency: 4.3 vs 3.9; intensity: 3.1 vs 2.8), Burping (frequency: 4.9 vs 4.4; intensity: 3.1 vs 2.8) and Hoarseness, cough and difficulty swallowing (frequency: 2.6 vs 2.2; intensity: 1.8 vs 1.5), and had higher GSRS domain discomfort scores than men for Abdominal pain (3.51 vs 3.23), Indigestion (3.80 vs 3.45) and Constipation (2.69 vs 2.17) (all <jats:italic>p<\/jats:italic> \u2009&lt;\u20090.05). Anxiety and depression were significantly more prevalent in women than in men.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>In this population of partial responders, women had more frequent\/intense heartburn and extra\u2010oesophageal symptoms and more discomfort from abdominal pain, indigestion and constipation than men. Comorbid anxiety and depression may contribute to the increased symptom burden in women.<\/jats:p><\/jats:sec>","DOI":"10.1177\/2050640614558343","type":"journal-article","created":{"date-parts":[[2014,11,5]],"date-time":"2014-11-05T03:28:23Z","timestamp":1415158103000},"page":"443-452","update-policy":"http:\/\/dx.doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":10,"title":["Gender differences in symptoms in partial responders to proton pump inhibitors for gastro\u2010oesophageal reflux disease"],"prefix":"10.1002","volume":"3","author":[{"given":"N","family":"Vakil","sequence":"first","affiliation":[{"name":"University of Wisconsin Medical School and Public Health Madison USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A","family":"Niklasson","sequence":"additional","affiliation":[{"name":"AstraZeneca R&amp;D M\u00f6lndal Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H","family":"Denison","sequence":"additional","affiliation":[{"name":"AstraZeneca R&amp;D M\u00f6lndal Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A","family":"Ryd\u00e9n","sequence":"additional","affiliation":[{"name":"AstraZeneca R&amp;D M\u00f6lndal 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